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repliedto MaziyarPanahi's post 15 days ago
Training mRNA Language Models Across 25 Species for $165 We built an end-to-end protein AI pipeline covering structure prediction, sequence design, and codon optimization. After comparing multiple transformer architectures for codon-level language modeling, CodonRoBERTa-large-v2 emerged as the clear winner with a perplexity of 4.10 and a Spearman CAI correlation of 0.40, significantly outperforming ModernBERT. We then scaled to 25 species, trained 4 production models in 55 GPU-hours, and built a species-conditioned system that no other open-source project offers. Complete results, architectural decisions, and runnable code below. https://huggingface.co/blog/OpenMed/training-mrna-models-25-species
reacted to danielhanchen's post with 🚀 15 days ago
You can now run Kimi K2.5 locally! 🔥 We shrank the 1T model to 240GB (-60%) via Dynamic 1-bit. Get >40 tok/s on 242GB or 622GB VRAM/RAM for near full precision. GGUF: https://huggingface.co/unsloth/Kimi-K2.5-GGUF Guide: https://unsloth.ai/docs/models/kimi-k2.5
reacted to Kseniase's post with 👍 15 days ago
10 Latest Preference Optimization Techniques Models need feedback on what makes outputs “good” or “bad.” Policy optimization (PO) turns preferences and rewards into actual training signals. This field is evolving quickly, moving far beyond classics like PPO and GRPO. So here is our overview of 10 newest PO methods: 1. Pref-GRPO → https://huggingface.co/papers/2508.20751 Stabilizes text-to-image reinforcement learning (RL) with pairwise preference rewards and a unified UNIGENBENCH benchmark 2. PVPO (Policy with Value Preference Optimization) → https://huggingface.co/papers/2508.21104 This critic-free RL method uses a pre-trained model as a reference anchor to reduce bias and guide learning, selecting high-value examples through data pre-sampling 3. DCPO (Dynamic Clipping Policy Optimization) → https://huggingface.co/papers/2509.02333 Uses dynamic clipping, which adjusts probability limits per token for better token exploration, and smooth reward standardization to balance rewards over training steps and prevent wasted updates 4. ARPO (Agentic Reinforced Policy Optimization) → https://huggingface.co/papers/2507.19849 Optimizes multi-turn LLM agents that use external tools. It uses an entropy-based adaptive rollout to explore post-tool use and an advantage attribution method to better assign credit across steps, leading to more efficient tool use with fewer resources 5. GRPO-RoC (Group Relative Policy Optimization with Resampling-on-Correct) → https://huggingface.co/papers/2508.20722 Oversamples rollouts, then resamples them to keep diverse mistakes and only the highest-quality correct answers. It reduces noises and ends up with stronger reasoning in a code environment Read further below ⬇️ If you like this, also subscribe to the Turing post: https://www.turingpost.com/subscribe
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