Daily Papers

Reinforcement learning with verifiable rewards (RLVR) is central to improving long-CoT reasoning in large language models. Critic-free methods such as GRPO convert response-level rewards into advantages and uniformly broadcast them across tokens, overlooking their unequal contributions to the final outcome. On-policy self-distillation (OPSD) instead provides dense distributional supervision by minimizing the forward KL divergence between an unprivileged policy and a privileged self-teacher, implicitly assuming that the resulting likelihood shifts encode reliable answer-aligned information. We test this premise by fixing each sampled trajectory and re-scoring it under two opposing outcome conditions, one asserting correctness and the other incorrectness. Most affected tokens shift in the same direction under both conditions, with few sign reversals and substantial overlap in the induced optimization signals. Large shifts also concentrate on highly substitutable surface-form tokens, whereas tokens carrying problem-specific reasoning content are less sensitive. These findings show that privileged shifts fail to provide reliable answer-aligned directions, while their magnitudes primarily reflect counterfactual sensitivity rather than token-level learning value. Based on these observations, we propose Counterfactual Sensitivity Credit Reallocation (CSCR), a simple extension of GRPO that reduces credit for highly sensitive tokens and renormalizes token-level advantages to preserve both the original credit budget and verifier-determined direction. On long-CoT mathematical reasoning benchmarks, CSCR consistently outperforms GRPO baseline with the same number of policy updates. Targeted ablations further corroborate our diagnosis: privilege-induced directions are unreliable, moderate downweighting is most effective, and stronger modulation destabilizes optimization.

Multimodal large language models (LLMs) are increasingly explored as automated evaluators in clinical settings, yet their scoring behavior on ordinal clinical scales remains poorly understood. We benchmark three frontier LLM families against supervised deep learning models for scoring Clock Drawing Test (CDT) images on two public datasets using the Shulman rubric. While fully fine-tuned Vision Transformers achieve the best calibration (MAE 0.52, within-1 accuracy 91%), zero-shot LLMs remain competitive on tolerance-based agreement (GPT-5 MAE 0.67, within-1 accuracy 92%) despite higher absolute error. However, per-score analysis reveals that all three LLM families exhibit a pronounced central tendency effect (systematic endpoint compression): predictions are systematically compressed toward the middle of the scale, with over-prediction at the low end (score 0 to 1) and under-prediction at the high end (score 5 to 4). This effect disproportionately affects the clinically critical extremes where accurate scoring most impacts screening decisions for cognitive impairment. Targeted ablations show that neither few-shot exemplars spanning the full score range nor removing clinical terminology from the prompt eliminates the effect. Our findings extend the LLM-as-a-judge bias literature from NLP evaluation to clinical assessment, and highlight the need for calibration-aware evaluation and post-hoc calibration before deploying LLM-based raters in high-stakes screening workflows.

Multi-expert systems, where multiple Large Language Models (LLMs) collaborate to solve complex tasks, are increasingly adopted for high-performance reasoning and generation. However, the orchestration policies governing expert interaction and sequencing remain largely opaque. We introduce INFORM, an interpretability analysis that treats orchestration as an explicit, analyzable computation, enabling the decoupling of expert interaction structure, execution order, and functional attribution. We use INFORM to evaluate an orchestrator on GSM8K, HumanEval, and MMLU using a homogeneous consortium of ten instruction-tuned experts drawn from LLaMA-3.1 8B, Qwen3 8B, and DeepSeek-R1 8B, with controlled decoding-temperature variation, and a secondary heterogeneous consortium spanning 1B-7B parameter models. Across tasks, routing dominance is a poor proxy for functional necessity. We reveal a divergence between relational importance, captured by routing mass and interaction topology, and intrinsic importance, measured via gradient sensitivity: frequently selected experts often act as interaction hubs with limited influence, while sparsely routed experts can be structurally critical. Orchestration behaviors emerge asynchronously, with expert centralization preceding stable routing confidence and expert ordering remaining non-deterministic. Targeted ablations show that masking intrinsically important experts induces disproportionate collapse in interaction structure compared to masking frequent peers, confirming that INFORM exposes functional and structural dependencies beyond accuracy metrics alone. Our code is available at https://github.com/parmanu-lcs2/inform.

Mechanism-targeted synthetic data is increasingly proposed as a way to steer pretraining toward desirable capabilities, but it remains unclear how such interventions should be evaluated. We study this question for in-context learning (ICL) under matched compute (iso-FLOPs) using Bi-Induct, a lightweight data rewrite that interleaves short directional copy snippets into a natural pretraining stream: forward-copy (induction), backward-copy (anti-induction, as a directional control), or a balanced mix. Across 0.13B-1B decoder-only models, we evaluate (i) few-shot performance on standard LM benchmarks and function-style ICL probes, (ii) head-level copy telemetry, and (iii) held-out perplexity as a guardrail. Bi-Induct reliably increases induction-head activity, but this does not translate into consistent improvements in few-shot generalization: on standard LM benchmarks, Bi-Induct is largely performance-neutral relative to natural-only training, while on function-style probes the 1B natural-only model performs best. Despite explicit backward-copy cues, anti-induction scores remain near zero across scales, revealing a strong forward/backward asymmetry. Targeted ablations show a sharper distinction: removing the top 2% induction heads per layer harms ICL more than matched random ablations, with the largest relative drop occurring in the natural-only models. This indicates that natural-only training produces more centralized, load-bearing induction circuitry, whereas Bi-Induct tends to create more distributed and redundant induction activity. Our main conclusion is that eliciting a mechanism is not the same as making it load-bearing. For data-centric foundation model design, this suggests that synthetic data interventions should be evaluated not only by signature amplification, but by whether they create causally necessary computation while preserving natural-data modeling quality.

Reinforcement learning with verifiable rewards has emerged as a promising paradigm for enhancing the reasoning capabilities of large language models particularly in mathematics. Current approaches in this domain present a clear trade-off: PPO-style methods (e.g., GRPO/DAPO) offer training stability but exhibit slow learning trajectories due to their trust-region constraints on policy updates, while REINFORCE-style approaches (e.g., CISPO) demonstrate improved learning efficiency but suffer from performance instability as they clip importance sampling weights while still permitting non-zero gradients outside the trust-region. To address these limitations, we introduce DISPO, a simple yet effective REINFORCE-style algorithm that decouples the up-clipping and down-clipping of importance sampling weights for correct and incorrect responses, yielding four controllable policy update regimes. Through targeted ablations, we uncover how each regime impacts training: for correct responses, weights >1 increase the average token entropy (i.e., exploration) while weights <1 decrease it (i.e., distillation) -- both beneficial but causing gradual performance degradation when excessive. For incorrect responses, overly restrictive clipping triggers sudden performance collapse through repetitive outputs (when weights >1) or vanishing response lengths (when weights <1). By separately tuning these four clipping parameters, DISPO maintains the exploration-distillation balance while preventing catastrophic failures, achieving 61.04% on AIME'24 (vs. 55.42% CISPO and 50.21% DAPO) with similar gains across various benchmarks and models.

Sparse Mixture-of-Experts (MoE) models scale capacity by routing each token to a small subset of experts. However, their routers exhibit a fundamental trade-off: strong load balancing can suppress expert specialization, while aggressive diversity often causes routing collapse. We propose Hi-MoE, a grouped MoE framework that decomposes routing control into two coupled levels: (i) inter-group balancing that enforces fair traffic across expert groups, and (ii) intra-group specialization that promotes complementary expert behaviors while preventing within-group collapse. Our analysis provides a principled explanation of how our hierarchical objectives reshape the router, thereby promoting stable specialization and mitigating collapse. We observe consistent improvements over recent sparse-routing and grouped-MoE baselines across NLP and vision benchmarks, and confirm robustness via scaling studies (model size, expert count) and targeted ablations. In large-scale pre-training on 58B tokens, Hi-MoE-7B achieves a 5.6% perplexity reduction and a 40% improvement in expert balance over OLMoE-7B across diverse evaluation domains.

We investigate the temporal concatenation of sub-policies in Markov Decision Processes (MDP) with time-varying reward functions. We introduce General Dijkstra Search (GDS), and prove that globally optimal goal-reaching policies can be recovered through temporal composition of intermediate optimal sub-policies. Motivated by the "search, select, update" principle underlying GDS, we propose Dynamic Latent Routing (DLR), a language-model post-training method that jointly learns discrete latent codes, routing policies, and model parameters through dynamic search in a single training stage. In low-data fine-tuning settings, DLR matches or outperforms supervised fine-tuning across four datasets and six models, achieving a mean gain of +6.6 percentage points, while prior discrete-latent baselines consistently underperform SFT. Mechanistic analyses and targeted code ablations show that DLR learns structured routing behaviors with distinct causal roles.

Large Multimodal Models (LMMs) are increasingly capable of answering medical questions that require joint reasoning over images and text, yet training general medical VQA systems is impeded by the lack of large, openly usable, high-quality corpora. We present MedVLSynther, a rubric-guided generator-verifier framework that synthesizes high-quality multiple-choice VQA items directly from open biomedical literature by conditioning on figures, captions, and in-text references. The generator produces self-contained stems and parallel, mutually exclusive options under a machine-checkable JSON schema; a multi-stage verifier enforces essential gates (self-containment, single correct answer, clinical validity, image-text consistency), awards fine-grained positive points, and penalizes common failure modes before acceptance. Applying this pipeline to PubMed Central yields MedSynVQA: 13,087 audited questions over 14,803 images spanning 13 imaging modalities and 28 anatomical regions. Training open-weight LMMs with reinforcement learning using verifiable rewards improves accuracy across six medical VQA benchmarks, achieving averages of 55.85 (3B) and 58.15 (7B), with up to 77.57 on VQA-RAD and 67.76 on PathVQA, outperforming strong medical LMMs. A Ablations verify that both generation and verification are necessary and that more verified data consistently helps, and a targeted contamination analysis detects no leakage from evaluation suites. By operating entirely on open literature and open-weight models, MedVLSynther offers an auditable, reproducible, and privacy-preserving path to scalable medical VQA training data.

The foundational pretraining phase determines a model's capability ceiling, as post-training struggles to overcome capability foundations established during pretraining, yet it remains critically under-explored. This stems from a structural paradox: organizations with computational resources operate under commercial pressures that inhibit transparent disclosure, while academic institutions possess research freedom but lack pretraining-scale computational resources. daVinci-LLM occupies this unexplored intersection, combining industrial-scale resources with full research freedom to advance the science of pretraining. We adopt a fully-open paradigm that treats openness as scientific methodology, releasing complete data processing pipelines, full training processes, and systematic exploration results. Recognizing that the field lacks systematic methodology for data processing, we employ the Data Darwinism framework, a principled L0-L9 taxonomy from filtering to synthesis. We train a 3B-parameter model from random initialization across 8T tokens using a two-stage adaptive curriculum that progressively shifts from foundational capabilities to reasoning-intensive enhancement. Through 200+ controlled ablations, we establish that: processing depth systematically enhances capabilities, establishing it as a critical dimension alongside volume scaling; different domains exhibit distinct saturation dynamics, necessitating adaptive strategies from proportion adjustments to format shifts; compositional balance enables targeted intensification while preventing performance collapse; how evaluation protocol choices shape our understanding of pretraining progress. By releasing the complete exploration process, we enable the community to build upon our findings and systematic methodologies to form accumulative scientific knowledge in pretraining.

Auto-harness systems such as A-Evolve, GEPA, and Meta-Harness improve LLM agents by optimizing prompts, skills, tools, memories, and supporting infrastructure from execution feedback, but they are typically evaluated on fixed offline benchmarks. Real deployments instead present open-ended task streams: histories grow without a fixed endpoint, heterogeneous tasks require different harnesses, and problem distributions shift over time. These challenges make a single repeatedly and densely updated harness brittle, causing performance degradation as accuracy peaks early and then declines. This motivates sustained harness construction with task-wise adaptation. We introduce Adaptive Auto-Harness, a framework and system for such streams. The framework decomposes the gap to an oracle harness into evolution loss and adaptation loss. The system addresses these losses with a stateful multi-agent evolver, a harness tree with solve-time routing, and human-steering hooks for cases where history lacks the needed signal. Across prediction-market, security-competition, and event-forecasting streams, Adaptive Auto-Harness outperforms five existing auto-harness baselines and ablations attribute gains to better construction, routing, or targeted human steering. Code is available in https://github.com/A-EVO-Lab/AdaptiveHarness .

AI agents are increasingly deployed in production, yet their security evaluations remain bottlenecked by manual red-teaming or static benchmarks that fail to model adaptive, multi-turn adversaries. We propose NAAMSE, an evolutionary framework that reframes agent security evaluation as a feedback-driven optimization problem. Our system employs a single autonomous agent that orchestrates a lifecycle of genetic prompt mutation, hierarchical corpus exploration, and asymmetric behavioral scoring. By using model responses as a fitness signal, the framework iteratively compounds effective attack strategies while simultaneously ensuring "benign-use correctness", preventing the degenerate security of blanket refusal. Our experiments on Gemini 2.5 Flash demonstrate that evolutionary mutation systematically amplifies vulnerabilities missed by one-shot methods, with controlled ablations revealing that the synergy between exploration and targeted mutation uncovers high-severity failure modes. We show that this adaptive approach provides a more realistic and scalable assessment of agent robustness in the face of evolving threats. The code for NAAMSE is open source and available at https://github.com/HASHIRU-AI/NAAMSE.

Fall recovery is a critical skill for humanoid robots in dynamic environments such as RoboCup, where prolonged downtime often decides the match. Recent techniques using deep reinforcement learning (DRL) have produced robust get-up behaviors, yet existing methods require training of separate policies for each robot morphology. This paper presents a single DRL policy capable of recovering from falls across seven humanoid robots with diverse heights (0.48 - 0.81 m), weights (2.8 - 7.9 kg), and dynamics. Trained with CrossQ, the unified policy transfers zero-shot up to 86 +/- 7% (95% CI [81, 89]) on unseen morphologies, eliminating the need for robot-specific training. Comprehensive leave-one-out experiments, morph scaling analysis, and diversity ablations show that targeted morphological coverage improves zero-shot generalization. In some cases, the shared policy even surpasses the specialist baselines. These findings illustrate the practicality of morphology-agnostic control for fall recovery, laying the foundation for generalist humanoid control. The software is open-source and available at: https://github.com/utra-robosoccer/unified-humanoid-getup

Current safety alignment for large language models(LLMs) continues to present vulnerabilities, given that adversarial prompting can effectively bypass their safety measures.Our investigation shows that these safety mechanisms predominantly depend on a limited subset of attention heads: removing or ablating these heads can severely compromise model safety. To identify and evaluate these safety-critical components, we introduce RDSHA, a targeted ablation method that leverages the model's refusal direction to pinpoint attention heads mostly responsible for safety behaviors. Further analysis shows that existing jailbreak attacks exploit this concentration by selectively bypassing or manipulating these critical attention heads. To address this issue, we propose AHD, a novel training strategy designed to promote the distributed encoding of safety-related behaviors across numerous attention heads. Experimental results demonstrate that AHD successfully distributes safety-related capabilities across more attention heads. Moreover, evaluations under several mainstream jailbreak attacks show that models trained with AHD exhibit considerably stronger safety robustness, while maintaining overall functional utility.

Large Language Models (LLMs) have demonstrated pronounced ideological leanings, yet the stability and depth of these positions remain poorly understood. Surface-level responses can often be manipulated through simple prompt engineering, calling into question whether they reflect a coherent underlying ideology. This paper investigates the concept of "ideological depth" in LLMs, defined as the robustness and complexity of their internal political representations. We employ a dual approach: first, we measure the "steerability" of two well-known open-source LLMs using instruction prompting and activation steering. We find that while some models can easily switch between liberal and conservative viewpoints, others exhibit resistance or an increased rate of refusal, suggesting a more entrenched ideological structure. Second, we probe the internal mechanisms of these models using Sparse Autoencoders (SAEs). Preliminary analysis reveals that models with lower steerability possess more distinct and abstract ideological features. Our evaluations reveal that one model can contain 7.3x more political features than another model of similar size. This allows targeted ablation of a core political feature in an ideologically "deep" model, leading to consistent, logical shifts in its reasoning across related topics, whereas the same intervention in a "shallow" model results in an increase in refusal outputs. Our findings suggest that ideological depth is a quantifiable property of LLMs and that steerability serves as a valuable window into their latent political architecture.

Focused Ultrasound Ablation Surgery (FUAS) has emerged as a promising non-invasive therapeutic modality, valued for its safety and precision. Nevertheless, its clinical implementation entails intricate tasks such as multimodal image interpretation, personalized dose planning, and real-time intraoperative decision-making processes that demand intelligent assistance to improve efficiency and reliability. We introduce FUAS-Agents, an autonomous agent system that leverages the multimodal understanding and tool-using capabilities of large language models (LLMs). By integrating patient profiles and MRI data, FUAS-Agents orchestrates a suite of specialized medical AI tools, including segmentation, treatment dose prediction, and clinical guideline retrieval, to generate personalized treatment plans comprising MRI image, dose parameters, and therapeutic strategies. We evaluate the system in a uterine fibroid treatment scenario. Human assessment by four senior FUAS experts indicates that 82.5%, 82.5%, 87.5%, and 97.5% of the generated plans were rated 4 or above (on a 5-point scale) in terms of completeness, accuracy, fluency, and clinical compliance, respectively. These results demonstrate the potential of LLM-driven agents in enhancing decision-making across complex clinical workflows, and exemplify a translational paradigm that combines general-purpose models with specialized expert systems to solve practical challenges in vertical healthcare domains.

This study presents a hybrid framework for predicting movie success. The framework integrates multi-task learning (MTL), GPT-based sentiment analysis, and Susceptible-Infected-Recovered (SIR) propagation modeling. The study examines limitations in existing approaches. It models static production attributes, information dissemination, and audience sentiment at the same time. The framework uses 5,840 films from 2004 to 2024 and approximate 300,000 user reviews. It shows predictive performance with classification accuracy of 0.964 and regression metrics of MAE 0.388. Ablation analysis indicates component interactions. Selective feature combinations perform better than the comprehensive model. This result questions assumptions about feature integration. The model shows virality patterns between successful and unsuccessful films. Innovations include epidemiological modeling for information diffusion, multidimensional sentiment features from GPT-based analysis, and a shared representation architecture that optimizes multiple success metrics. The framework provides applications in the film production lifecycle. It also contributes to understanding how audience engagement leads to commercial outcomes.

ECG foundation models are increasingly popular due to their adaptability across various tasks. However, their clinical applicability is often limited by performance gaps compared to task-specific models, even after pre-training on large ECG datasets and fine-tuning on target data. This limitation is likely due to the lack of an effective post-training strategy. In this paper, we propose a simple yet effective post-training approach to enhance ECG foundation models. We evaluate it on a publicly available Transformer-based foundation model. Experiments across multiple ECG tasks show that our method consistently outperforms baseline fine-tuning. On the PTB-XL benchmarks, it improves macro AUROC by 0.7%-8.9% and macro AUPRC by 23.3%-77.9%, also outperforming several recent state-of-the-art approaches, including task-specific and advanced architectures. Further analyses demonstrate improved training dynamics and data efficiency, with only 30% of the training data outperforming the baseline trained on the full dataset. Ablation studies highlight the importance of stochastic depth and preview linear probing. These findings underscore the potential of post-training strategies to improve ECG foundation models, and we hope this work will contribute to the continued development of foundation models in the ECG domain.

The rapid increase of computed tomography (CT) scans and their time-consuming manual analysis have created an urgent need for robust automated analysis techniques in clinical settings. These aim to assist radiologists and help them managing their growing workload. Existing methods typically generate entire reports directly from 3D CT images, without explicitly focusing on observed abnormalities. This unguided approach often results in repetitive content or incomplete reports, failing to prioritize anomaly-specific descriptions. We propose a new anomaly-guided report generation model, which first predicts abnormalities and then generates targeted descriptions for each. Evaluation on a public dataset demonstrates significant improvements in report quality and clinical relevance. We extend our work by conducting an ablation study to demonstrate its effectiveness.

Structure-based drug design (SBDD) aims to discover drug candidates by finding molecules (ligands) that bind tightly to a disease-related protein (targets), which is the primary approach to computer-aided drug discovery. Recently, applying deep generative models for three-dimensional (3D) molecular design conditioned on protein pockets to solve SBDD has attracted much attention, but their formulation as probabilistic modeling often leads to unsatisfactory optimization performance. On the other hand, traditional combinatorial optimization methods such as genetic algorithms (GA) have demonstrated state-of-the-art performance in various molecular optimization tasks. However, they do not utilize protein target structure to inform design steps but rely on a random-walk-like exploration, which leads to unstable performance and no knowledge transfer between different tasks despite the similar binding physics. To achieve a more stable and efficient SBDD, we propose Reinforced Genetic Algorithm (RGA) that uses neural models to prioritize the profitable design steps and suppress random-walk behavior. The neural models take the 3D structure of the targets and ligands as inputs and are pre-trained using native complex structures to utilize the knowledge of the shared binding physics from different targets and then fine-tuned during optimization. We conduct thorough empirical studies on optimizing binding affinity to various disease targets and show that RGA outperforms the baselines in terms of docking scores and is more robust to random initializations. The ablation study also indicates that the training on different targets helps improve performance by leveraging the shared underlying physics of the binding processes. The code is available at https://github.com/futianfan/reinforced-genetic-algorithm.

We revisit the problem of large-scale bundle adjustment and propose a technique called Multidirectional Conjugate Gradients that accelerates the solution of the normal equation by up to 61%. The key idea is that we enlarge the search space of classical preconditioned conjugate gradients to include multiple search directions. As a consequence, the resulting algorithm requires fewer iterations, leading to a significant speedup of large-scale reconstruction, in particular for denser problems where traditional approaches notoriously struggle. We provide a number of experimental ablation studies revealing the robustness to variations in the hyper-parameters and the speedup as a function of problem density.

Ablation studies have been widely used in the field of neuroscience to tackle complex biological systems such as the extensively studied Drosophila central nervous system, the vertebrate brain and more interestingly and most delicately, the human brain. In the past, these kinds of studies were utilized to uncover structure and organization in the brain, i.e. a mapping of features inherent to external stimuli onto different areas of the neocortex. considering the growth in size and complexity of state-of-the-art artificial neural networks (ANNs) and the corresponding growth in complexity of the tasks that are tackled by these networks, the question arises whether ablation studies may be used to investigate these networks for a similar organization of their inner representations. In this paper, we address this question and performed two ablation studies in two fundamentally different ANNs to investigate their inner representations of two well-known benchmark datasets from the computer vision domain. We found that features distinct to the local and global structure of the data are selectively represented in specific parts of the network. Furthermore, some of these representations are redundant, awarding the network a certain robustness to structural damages. We further determined the importance of specific parts of the network for the classification task solely based on the weight structure of single units. Finally, we examined the ability of damaged networks to recover from the consequences of ablations by means of recovery training. We argue that ablations studies are a feasible method to investigate knowledge representations in ANNs and are especially helpful to examine a networks robustness to structural damages, a feature of ANNs that will become increasingly important for future safety-critical applications.

We develop a portfolio allocation framework that leverages deep learning techniques to address challenges arising from high-dimensional, non-stationary, and low-signal-to-noise market information. Our approach includes a dynamic embedding method that reduces the non-stationary, high-dimensional state space into a lower-dimensional representation. We design a reinforcement learning (RL) framework that integrates generative autoencoders and online meta-learning to dynamically embed market information, enabling the RL agent to focus on the most impactful parts of the state space for portfolio allocation decisions. Empirical analysis based on the top 500 U.S. stocks demonstrates that our framework outperforms common portfolio benchmarks and the predict-then-optimize (PTO) approach using machine learning, particularly during periods of market stress. Traditional factor models do not fully explain this superior performance. The framework's ability to time volatility reduces its market exposure during turbulent times. Ablation studies confirm the robustness of this performance across various reinforcement learning algorithms. Additionally, the embedding and meta-learning techniques effectively manage the complexities of high-dimensional, noisy, and non-stationary financial data, enhancing both portfolio performance and risk management.

The FRIB heavy-ion accelerator, commissioned in 2022, is a leading facility for producing rare isotope beams (RIBs) and exploring nuclei beyond the limits of stability. These RIBs are produced via reactions between stable primary beams and a graphite target. Approximately 20-40 \% of the primary beam power is deposited in the target, requiring efficient thermal dissipation. Currently, FRIB operates with a primary beam power of up to 20 kW. To enhance thermal dissipation efficiency, a single-slice rotating graphite target with a diameter of approximately 30 cm is employed. The effective target region is a 1 cm-wide outer rim of the graphite disc. To achieve high RIB production rates, the areal thickness variation must be constrained within 2 \%. This paper presents physical thickness characterizations of FRIB production targets with various nominal thicknesses, measured using a custom-built non-contact thickness measurement apparatus.

Clinical MRI encompasses diverse imaging protocols--spanning anatomical targets (cardiac, brain, knee), contrasts (T1, T2, mapping), sampling patterns (Cartesian, radial, spiral, kt-space), and acceleration factors--yet current deep learning reconstructions are typically protocol-specific, hindering generalization and deployment. We introduce Scalable Deep Unrolled Model (SDUM), a universal framework combining a Restormer-based reconstructor, a learned coil sensitivity map estimator (CSME), sampling-aware weighted data consistency (SWDC), universal conditioning (UC) on cascade index and protocol metadata, and progressive cascade expansion training. SDUM exhibits foundation-model-like scaling behavior: reconstruction quality follows PSNR {sim} log(parameters) with correlation r{=}0.986 (R^2{=}0.973) up to 18 cascades, demonstrating predictable performance gains with model depth. A single SDUM trained on heterogeneous data achieves state-of-the-art results across all four CMRxRecon2025 challenge tracks--multi-center, multi-disease, 5T, and pediatric--without task-specific fine-tuning, surpassing specialized baselines by up to {+}1.0~dB. On CMRxRecon2024, SDUM outperforms the winning method PromptMR+ by {+}0.55~dB; on fastMRI brain, it exceeds PC-RNN by {+}1.8~dB. Ablations validate each component: SWDC {+}0.43~dB over standard DC, per-cascade CSME {+}0.51~dB, UC {+}0.38~dB. These results establish SDUM as a practical path toward universal, scalable MRI reconstruction.

We present ENSAM (Equivariant, Normalized, Segment Anything Model), a lightweight and promptable model for universal 3D medical image segmentation. ENSAM combines a SegResNet-based encoder with a prompt encoder and mask decoder in a U-Net-style architecture, using latent cross-attention, relative positional encoding, normalized attention, and the Muon optimizer for training. ENSAM is designed to achieve good performance under limited data and computational budgets, and is trained from scratch on under 5,000 volumes from multiple modalities (CT, MRI, PET, ultrasound, microscopy) on a single 32 GB GPU in 6 hours. As part of the CVPR 2025 Foundation Models for Interactive 3D Biomedical Image Segmentation Challenge, ENSAM was evaluated on hidden test set with multimodal 3D medical images, obtaining a DSC AUC of 2.404, NSD AUC of 2.266, final DSC of 0.627, and final NSD of 0.597, outperforming two previously published baseline models (VISTA3D, SAM-Med3D) and matching the third (SegVol), surpassing its performance in final DSC but trailing behind in the other three metrics. In the coreset track of the challenge, ENSAM ranks 5th of 10 overall and best among the approaches not utilizing pretrained weights. Ablation studies confirm that our use of relative positional encodings and the Muon optimizer each substantially speed up convergence and improve segmentation quality.

Understanding the irregular electrical activity of atrial fibrillation (AFib) has been a key challenge in electrocardiography. For serious cases of AFib, catheter ablations are performed to collect intracardiac electrograms (EGMs). EGMs offer intricately detailed and localized electrical activity of the heart and are an ideal modality for interpretable cardiac studies. Recent advancements in artificial intelligence (AI) has allowed some works to utilize deep learning frameworks to interpret EGMs during AFib. Additionally, language models (LMs) have shown exceptional performance in being able to generalize to unseen domains, especially in healthcare. In this study, we are the first to leverage pretrained LMs for finetuning of EGM interpolation and AFib classification via masked language modeling. We formulate the EGM as a textual sequence and present competitive performances on AFib classification compared against other representations. Lastly, we provide a comprehensive interpretability study to provide a multi-perspective intuition of the model's behavior, which could greatly benefit the clinical use.

We introduce AbGen, the first benchmark designed to evaluate the capabilities of LLMs in designing ablation studies for scientific research. AbGen consists of 1,500 expert-annotated examples derived from 807 NLP papers. In this benchmark, LLMs are tasked with generating detailed ablation study designs for a specified module or process based on the given research context. Our evaluation of leading LLMs, such as DeepSeek-R1-0528 and o4-mini, highlights a significant performance gap between these models and human experts in terms of the importance, faithfulness, and soundness of the ablation study designs. Moreover, we demonstrate that current automated evaluation methods are not reliable for our task, as they show a significant discrepancy when compared to human assessment. To better investigate this, we develop AbGen-Eval, a meta-evaluation benchmark designed to assess the reliability of commonly used automated evaluation systems in measuring LLM performance on our task. We investigate various LLM-as-Judge systems on AbGen-Eval, providing insights for future research on developing more effective and reliable LLM-based evaluation systems for complex scientific tasks.

Over the last decade, online lecture videos have become increasingly popular and have experienced a meteoric rise during the pandemic. However, video-language research has primarily focused on instructional videos or movies, and tools to help students navigate the growing online lectures are lacking. Our first contribution is to facilitate research in the educational domain, by introducing AVLectures, a large-scale dataset consisting of 86 courses with over 2,350 lectures covering various STEM subjects. Each course contains video lectures, transcripts, OCR outputs for lecture frames, and optionally lecture notes, slides, assignments, and related educational content that can inspire a variety of tasks. Our second contribution is introducing video lecture segmentation that splits lectures into bite-sized topics that show promise in improving learner engagement. We formulate lecture segmentation as an unsupervised task that leverages visual, textual, and OCR cues from the lecture, while clip representations are fine-tuned on a pretext self-supervised task of matching the narration with the temporally aligned visual content. We use these representations to generate segments using a temporally consistent 1-nearest neighbor algorithm, TW-FINCH. We evaluate our method on 15 courses and compare it against various visual and textual baselines, outperforming all of them. Our comprehensive ablation studies also identify the key factors driving the success of our approach.

Increasingly advanced data augmentation techniques have greatly aided clinical medical research, increasing data diversity and improving model generalization capabilities. Although most current basic models exhibit strong generalization abilities, image quality varies due to differences in equipment and operators. To address these challenges, we present SegTTA, a framework that improves medical image segmentation without model retraining by combining four augmentations (Gamma correction, Contrast enhancement, Gaussian blur, Gaussian noise) with weighted voting across multiple MedSAM2 checkpoints. Experiments demonstrate consistent improvements across three diverse datasets: healthy uterus segmentation, uterine myoma detection, and multi class hepatic structure segmentation. Ablation studies reveal that large organs benefit from intensity augmentations while small lesions require noise augmentations. The voting threshold controls the coverage precision trade off, enabling task specific optimization for different clinical requirements. Ultimately, on a multiclass hepatic vessel dataset, compared to MedSAM2 baselines, our method achieves an increase of 1.6 in mIoU and 1.9 in aIoU, along with a reduction of approximately 2.0 in HD95. Code will be available at https://github.com/AIGeeksGroup/SegTTA.

This study quantifies the association between non-adherence to antipsychotic medications and adverse outcomes in individuals with schizophrenia. We frame the problem using survival analysis, focusing on the time to the earliest of several adverse events (early death, involuntary hospitalization, jail booking). We extend standard causal inference methods (T-learner, S-learner, nearest neighbor matching) to utilize various survival models to estimate individual and average treatment effects, where treatment corresponds to medication non-adherence. Analyses are repeated using different amounts of longitudinal information (3, 6, 9, and 12 months). Using data from Allegheny County in western Pennsylvania, we find strong evidence that non-adherence advances adverse outcomes by approximately 1 to 4 months. Ablation studies confirm that county-provided risk scores adjust for key confounders, as their removal amplifies the estimated effects. Subgroup analyses by medication formulation (injectable vs. oral) and medication type consistently show that non-adherence is associated with earlier adverse events. These findings highlight the clinical importance of adherence in delaying psychiatric crises and show that integrating survival analysis with causal inference tools can yield policy-relevant insights. We caution that although we apply causal inference, we only make associative claims and discuss assumptions needed for causal interpretation.

Autonomous agents built on language models (LMs) are showing increasing popularity in many fields, including scientific research. AI co-scientists aim to support or automate parts of the research process using these agents. A key component of empirical AI research is the design of ablation experiments. To this end, we introduce AblationBench, a benchmark suite for evaluating agents on ablation planning tasks in empirical AI research. It includes two tasks: AuthorAblation, which helps authors propose ablation experiments based on a method section and contains 83 instances, and ReviewerAblation, which helps reviewers find missing ablations in a full paper and contains 350 instances. For both tasks, we develop LM-based judges that serve as an automatic evaluation framework. Our experiments with frontier LMs show that these tasks remain challenging, with the best-performing LM system identifying only 29% of the original ablations on average. Lastly, we analyze the limitations of current LMs on these tasks, and find that chain-of-thought prompting outperforms the currently existing agent-based approach.

Controlling the COVID-19 pandemic largely hinges upon the existence of fast, safe, and highly-available diagnostic tools. Ultrasound, in contrast to CT or X-Ray, has many practical advantages and can serve as a globally-applicable first-line examination technique. We provide the largest publicly available lung ultrasound (US) dataset for COVID-19 consisting of 106 videos from three classes (COVID-19, bacterial pneumonia, and healthy controls); curated and approved by medical experts. On this dataset, we perform an in-depth study of the value of deep learning methods for differential diagnosis of COVID-19. We propose a frame-based convolutional neural network that correctly classifies COVID-19 US videos with a sensitivity of 0.98+-0.04 and a specificity of 0.91+-08 (frame-based sensitivity 0.93+-0.05, specificity 0.87+-0.07). We further employ class activation maps for the spatio-temporal localization of pulmonary biomarkers, which we subsequently validate for human-in-the-loop scenarios in a blindfolded study with medical experts. Aiming for scalability and robustness, we perform ablation studies comparing mobile-friendly, frame- and video-based architectures and show reliability of the best model by aleatoric and epistemic uncertainty estimates. We hope to pave the road for a community effort toward an accessible, efficient and interpretable screening method and we have started to work on a clinical validation of the proposed method. Data and code are publicly available.

Understanding how deep learning models predict oncology patient risk can provide critical insights into disease progression, support clinical decision-making, and pave the way for trustworthy and data-driven precision medicine. Building on recent advances in the spatial modeling of the tumor microenvironment using graph neural networks, we present an explainable cell graph (xCG) approach for survival prediction. We validate our model on a public cohort of imaging mass cytometry (IMC) data for 416 cases of lung adenocarcinoma. We explain survival predictions in terms of known phenotypes on the cell level by computing risk attributions over cell graphs, for which we propose an efficient grid-based layer-wise relevance propagation (LRP) method. Our ablation studies highlight the importance of incorporating the cancer stage and model ensembling to improve the quality of risk estimates. Our xCG method, together with the IMC data, is made publicly available to support further research.

Following recent advancements in computer-aided detection and diagnosis systems for colonoscopy, the automated reporting of colonoscopy procedures is set to further revolutionize clinical practice. A crucial yet underexplored aspect in the development of these systems is the creation of computer vision models capable of autonomously segmenting full-procedure colonoscopy videos into anatomical sections and procedural phases. In this work, we aim to create the first open-access dataset for this task and propose a state-of-the-art approach, benchmarked against competitive models. We annotated the publicly available REAL-Colon dataset, consisting of 2.7 million frames from 60 complete colonoscopy videos, with frame-level labels for anatomical locations and colonoscopy phases across nine categories. We then present ColonTCN, a learning-based architecture that employs custom temporal convolutional blocks designed to efficiently capture long temporal dependencies for the temporal segmentation of colonoscopy videos. We also propose a dual k-fold cross-validation evaluation protocol for this benchmark, which includes model assessment on unseen, multi-center data.ColonTCN achieves state-of-the-art performance in classification accuracy while maintaining a low parameter count when evaluated using the two proposed k-fold cross-validation settings, outperforming competitive models. We report ablation studies to provide insights into the challenges of this task and highlight the benefits of the custom temporal convolutional blocks, which enhance learning and improve model efficiency. We believe that the proposed open-access benchmark and the ColonTCN approach represent a significant advancement in the temporal segmentation of colonoscopy procedures, fostering further open-access research to address this clinical need.

Leaf-lesion segmentation is topology-sensitive: small merges, splits, or false holes can be biologically meaningful descriptors of biochemical pathways, yet they are weakly penalized by standard pixel-wise losses in Euclidean latents. I explore HyperTopo-Adapters, a lightweight, parameter-efficient head trained on top of a frozen vision encoder, which embeds features on a product manifold -- hyperbolic + Euclidean + spherical (H + E + S) -- to encourage hierarchical separation (H), local linear detail (E), and global closure (S). A topology prior complements Dice/BCE in two forms: (i) persistent-homology (PH) distance for evaluation and selection, and (ii) a differentiable surrogate that combines a soft Euler-characteristic match with total variation regularization for stable training. I introduce warm-ups for both the hyperbolic contrastive term and the topology prior, per-sample evaluation of structure-aware metrics (Boundary-F1, Betti errors, PD distance), and a min-PD within top-K Dice rule for checkpoint selection. On a Kaggle leaf-lesion dataset (N=2,940), early results show consistent gains in boundary and topology metrics (reducing Delta beta_1 hole error by 9%) while Dice/IoU remain competitive. The study is diagnostic by design: I report controlled ablations (curvature learning, latent dimensions, contrastive temperature, surrogate settings), and ongoing tests varying encoder strength (ResNet-50, DeepLabV3, DINOv2/v3), input resolution, PH weight, and partial unfreezing of late blocks. The contribution is an open, reproducible train/eval suite (available at https://github.com/ChimdiWalter/HyperTopo-Adapters) that isolates geometric/topological priors and surfaces failure modes to guide stronger, topology-preserving architectures.

We present 360Zhinao models with 7B parameter size and context lengths spanning 4K, 32K and 360K, all available at https://github.com/Qihoo360/360zhinao. For rapid development in pretraining, we establish a stable and sensitive ablation environment to evaluate and compare experiment runs with minimal model size. Under such guidance, we perfect our data cleaning and composition strategies to pretrain 360Zhinao-7B-Base on 3.4T tokens. We also mainly emphasize data during alignment, where we strive to balance quantity and quality with filtering and reformatting. With tailored data, 360Zhinao-7B's context window is easily extended to 32K and 360K. RMs and RLHF are trained following SFT and credibly applied to specific tasks. All together these contributions lead to 360Zhinao-7B's competitive performance among models of similar size.

Deep learning brought boosts to auto diabetic retinopathy (DR) diagnosis, thus, greatly helping ophthalmologists for early disease detection, which contributes to preventing disease deterioration that may eventually lead to blindness. It has been proved that convolutional neural network (CNN)-aided lesion identifying or segmentation benefits auto DR screening. The key to fine-grained lesion tasks mainly lies in: (1) extracting features being both sensitive to tiny lesions and robust against DR-irrelevant interference, and (2) exploiting and re-using encoded information to restore lesion locations under extremely imbalanced data distribution. To this end, we propose a CNN-based DR diagnosis network with attention mechanism involved, termed lesion-aware network, to better capture lesion information from imbalanced data. Specifically, we design the lesion-aware module (LAM) to capture noise-like lesion areas across deeper layers, and the feature-preserve module (FPM) to assist shallow-to-deep feature fusion. Afterward, the proposed lesion-aware network (LANet) is constructed by embedding the LAM and FPM into the CNN decoders for DR-related information utilization. The proposed LANet is then further extended to a DR screening network by adding a classification layer. Through experiments on three public fundus datasets with pixel-level annotations, our method outperforms the mainstream methods with an area under curve of 0.967 in DR screening, and increases the overall average precision by 7.6%, 2.1%, and 1.2% in lesion segmentation on three datasets. Besides, the ablation study validates the effectiveness of the proposed sub-modules.

A novel gradient boosting framework is proposed where shallow neural networks are employed as ``weak learners''. General loss functions are considered under this unified framework with specific examples presented for classification, regression, and learning to rank. A fully corrective step is incorporated to remedy the pitfall of greedy function approximation of classic gradient boosting decision tree. The proposed model rendered outperforming results against state-of-the-art boosting methods in all three tasks on multiple datasets. An ablation study is performed to shed light on the effect of each model components and model hyperparameters.

Even though convolutional neural networks (CNNs) are driving progress in medical image segmentation, standard models still have some drawbacks. First, the use of multi-scale approaches, i.e., encoder-decoder architectures, leads to a redundant use of information, where similar low-level features are extracted multiple times at multiple scales. Second, long-range feature dependencies are not efficiently modeled, resulting in non-optimal discriminative feature representations associated with each semantic class. In this paper we attempt to overcome these limitations with the proposed architecture, by capturing richer contextual dependencies based on the use of guided self-attention mechanisms. This approach is able to integrate local features with their corresponding global dependencies, as well as highlight interdependent channel maps in an adaptive manner. Further, the additional loss between different modules guides the attention mechanisms to neglect irrelevant information and focus on more discriminant regions of the image by emphasizing relevant feature associations. We evaluate the proposed model in the context of semantic segmentation on three different datasets: abdominal organs, cardiovascular structures and brain tumors. A series of ablation experiments support the importance of these attention modules in the proposed architecture. In addition, compared to other state-of-the-art segmentation networks our model yields better segmentation performance, increasing the accuracy of the predictions while reducing the standard deviation. This demonstrates the efficiency of our approach to generate precise and reliable automatic segmentations of medical images. Our code is made publicly available at https://github.com/sinAshish/Multi-Scale-Attention

Strictly proper scoring rules identify the true conditional class distribution at population level, but their curvature can alter optimization and finite-sample behavior. We study three multiclass objectives: a class-aware quadratic Bregman score (CAPM), a strongly convex generator with constrained log-cosh ridges (HPG), and an HPG objective with an annealed probability-margin penalty (APMS). CAPM is treated as a structured instance of established quadratic scoring-rule theory. We derive conditional-regret, curvature, range, and logit-gradient bounds for CAPM and HPG, and prove exact penalty-range and conditional-target displacement bounds for APMS. Controlled five-seed experiments use Digits, Wisconsin breast cancer, and synthetic confusion and long-tail problems under clean labels, symmetric and pair-flip corruption, class imbalance, calibration evaluation, input corruption, and first-order adversarial perturbations. The candidates are close to cross-entropy on clean data and show descriptive gains in some noisy-label cells, but the five-seed comparisons are interpreted descriptively rather than as significance evidence. The selected noisy-label baselines perform better on Digits with 40% symmetric label noise, and explicit prior-adjustment methods perform better in the 30:1 synthetic long-tail experiment. Ablations do not show a consistent benefit from the candidate-specific graph, ridge, or margin components. The mathematical analysis establishes the stated properties, and the experiments delimit the empirical evidence; together they do not support a claim of general superiority.

Camouflaged object segmentation presents unique challenges compared to traditional segmentation tasks, primarily due to the high similarity in patterns and colors between camouflaged objects and their backgrounds. Effective solutions to this problem have significant implications in critical areas such as pest control, defect detection, and lesion segmentation in medical imaging. Prior research has predominantly emphasized supervised or unsupervised pre-training methods, leaving zero-shot approaches significantly underdeveloped. Existing zero-shot techniques commonly utilize the Segment Anything Model (SAM) in automatic mode or rely on vision-language models to generate cues for segmentation; however, their performances remain unsatisfactory, due to the similarity of the camouflaged object and the background. This work studies how to avoid training by integrating large pre-trained models like SAM-2 and Owl-v2 with temporal information into a modular pipeline. Evaluated on the MoCA-Mask dataset, our approach achieves outstanding performance improvements, significantly outperforming existing zero-shot methods by raising the F-measure (F_beta^w) from 0.296 to 0.628. Our approach also surpasses supervised methods, increasing the F-measure from 0.476 to 0.628. Additionally, evaluation on the MoCA-Filter dataset demonstrates an increase in the success rate from 0.628 to 0.697 when compared with FlowSAM, a supervised transfer method. A thorough ablation study further validates the individual contributions of each component. Besides our main contributions, we also highlight inconsistencies in previous work regarding metrics and settings. Code can be found in https://github.com/weathon/vcos.

Large vision-language models (VLMs) are increasingly deployed for optical character recognition (OCR) in healthcare settings, raising critical concerns about protected health information (PHI) exposure during document processing. This work presents the first systematic evaluation of inference-time vision token masking as a privacy-preserving mechanism for medical document OCR using DeepSeek-OCR. We introduce seven masking strategies (V3-V9) targeting different architectural layers (SAM encoder blocks, compression layers, dual vision encoders, projector fusion) and evaluate PHI reduction across HIPAA-defined categories using 100 synthetic medical billing statements (drawn from a corpus of 38,517 annotated documents) with perfect ground-truth annotations. All masking strategies converge to 42.9% PHI reduction, successfully suppressing long-form spatially-distributed identifiers (patient names, dates of birth, physical addresses at 100% effectiveness) while failing to prevent short structured identifiers (medical record numbers, social security numbers, email addresses, account numbers at 0% effectiveness). Ablation studies varying mask expansion radius (r=1,2,3) demonstrate that increased spatial coverage does not improve reduction beyond this ceiling, indicating that language model contextual inference - not insufficient visual masking - drives structured identifier leakage. A simulated hybrid architecture combining vision masking with NLP post-processing achieves 88.6% total PHI reduction (assuming 80% NLP accuracy on remaining identifiers). This negative result establishes boundaries for vision-only privacy interventions in VLMs, provides guidance distinguishing PHI types amenable to vision-level versus language-level redaction, and redirects future research toward decoder-level fine-tuning and hybrid defense-in-depth architectures for HIPAA-compliant medical document processing.

Fetoscopy laser photocoagulation is a widely used procedure for the treatment of Twin-to-Twin Transfusion Syndrome (TTTS), that occur in mono-chorionic multiple pregnancies due to placental vascular anastomoses. This procedure is particularly challenging due to limited field of view, poor manoeuvrability of the fetoscope, poor visibility due to fluid turbidity, variability in light source, and unusual position of the placenta. This may lead to increased procedural time and incomplete ablation, resulting in persistent TTTS. Computer-assisted intervention may help overcome these challenges by expanding the fetoscopic field of view through video mosaicking and providing better visualization of the vessel network. However, the research and development in this domain remain limited due to unavailability of high-quality data to encode the intra- and inter-procedure variability. Through the Fetoscopic Placental Vessel Segmentation and Registration (FetReg) challenge, we present a large-scale multi-centre dataset for the development of generalized and robust semantic segmentation and video mosaicking algorithms for the fetal environment with a focus on creating drift-free mosaics from long duration fetoscopy videos. In this paper, we provide an overview of the FetReg dataset, challenge tasks, evaluation metrics and baseline methods for both segmentation and registration. Baseline methods results on the FetReg dataset shows that our dataset poses interesting challenges, offering large opportunity for the creation of novel methods and models through a community effort initiative guided by the FetReg challenge.

In this paper, we tackle the important yet under-investigated problem of making long-horizon prediction of event sequences. Existing state-of-the-art models do not perform well at this task due to their autoregressive structure. We propose HYPRO, a hybridly normalized probabilistic model that naturally fits this task: its first part is an autoregressive base model that learns to propose predictions; its second part is an energy function that learns to reweight the proposals such that more realistic predictions end up with higher probabilities. We also propose efficient training and inference algorithms for this model. Experiments on multiple real-world datasets demonstrate that our proposed HYPRO model can significantly outperform previous models at making long-horizon predictions of future events. We also conduct a range of ablation studies to investigate the effectiveness of each component of our proposed methods.

Large language models (LLMs) are increasingly used in healthcare, but their reliability is heavily influenced by user-driven factors such as question phrasing and the completeness of clinical information. In this study, we examined how misinformation framing, source authority, model persona, and omission of key clinical details affect the diagnostic accuracy and reliability of LLM outputs. We conducted two experiments: one introducing misleading external opinions with varying assertiveness (perturbation test), and another removing specific categories of patient information (ablation test). Using public datasets (MedQA and Medbullets), we evaluated proprietary models (GPT-4o, Claude 3.5 Sonnet, Claude 3.5 Haiku, Gemini 1.5 Pro, Gemini 1.5 Flash) and open-source models (LLaMA 3 8B, LLaMA 3 Med42 8B, DeepSeek R1 8B). All models were vulnerable to user-driven misinformation, with proprietary models especially affected by definitive and authoritative language. Assertive tone had the greatest negative impact on accuracy. In the ablation test, omitting physical exam findings and lab results caused the most significant performance drop. Although proprietary models had higher baseline accuracy, their performance declined sharply under misinformation. These results highlight the need for well-structured prompts and complete clinical context. Users should avoid authoritative framing of misinformation and provide full clinical details, especially for complex cases.

In many industries, predicting metric outcomes of large systems is a fundamental problem, driven largely by traditional tabular regression. However, such methods struggle on complex systems data in the wild such as configuration files or system logs, where feature engineering is often infeasible. We propose text-to-text regression as a general, scalable alternative. For predicting resource efficiency on Borg, Google's massive compute cluster scheduling system, a 60M parameter encoder-decoder, trained from random initialization, achieves up to a near perfect 0.99 (0.9 average) rank correlation across the entire fleet, and 100x lower MSE than tabular approaches. The model also easily adapts to new tasks in only 500 few-shot examples and captures the densities of complex outcome distributions. Ablation studies highlight the importance of using encoders, increasing sequence length, and the model's inherent uncertainty quantification. These findings pave the way for universal simulators of real-world outcomes.

We introduce HouseCrafter, a novel approach that can lift a floorplan into a complete large 3D indoor scene (e.g., a house). Our key insight is to adapt a 2D diffusion model, which is trained on web-scale images, to generate consistent multi-view color (RGB) and depth (D) images across different locations of the scene. Specifically, the RGB-D images are generated autoregressively in a batch-wise manner along sampled locations based on the floorplan, where previously generated images are used as condition to the diffusion model to produce images at nearby locations. The global floorplan and attention design in the diffusion model ensures the consistency of the generated images, from which a 3D scene can be reconstructed. Through extensive evaluation on the 3D-Front dataset, we demonstrate that HouseCraft can generate high-quality house-scale 3D scenes. Ablation studies also validate the effectiveness of different design choices. We will release our code and model weights. Project page: https://neu-vi.github.io/houseCrafter/

Multivariate time series anomalies often manifest as shifts in cross-channel dependencies rather than simple amplitude excursions. In autonomous driving, for instance, a steering command might be internally consistent but decouple from the resulting lateral acceleration. Residual-based detectors can miss such anomalies when flexible sequence models still reconstruct signals plausibly despite altered coordination. We introduce AxonAD, an unsupervised detector that treats multi-head attention query evolution as a short horizon predictable process. A gradient-updated reconstruction pathway is coupled with a history-only predictor that forecasts future query vectors from past context. This is trained via a masked predictor-target objective against an exponential moving average (EMA) target encoder. At inference, reconstruction error is combined with a tail-aggregated query mismatch score, which measures cosine deviation between predicted and target queries on recent timesteps. This dual approach provides sensitivity to structural dependency shifts while retaining amplitude-level detection. On proprietary in-vehicle telemetry with interval annotations and on the TSB-AD multi-variate suite (17 datasets, 180 series) with threshold-free and range-aware metrics, AxonAD improves ranking quality and temporal localization over strong baselines. Ablations confirm that query prediction and combined scoring are the primary drivers of the observed gains. Code is available at the URL https://github.com/iis-esslingen/AxonAD.

Instruction tuning enhances large language models (LLMs) to follow human instructions across diverse tasks, relying on high-quality datasets to guide behavior. However, these datasets, whether manually curated or synthetically generated, are often narrowly focused and misaligned with the broad distributions captured during pre-training, limiting LLM generalization and effective use of pre-trained knowledge. We propose Aligning Instruction Tuning with Pre-training (AITP), a method that bridges this gap by identifying coverage shortfalls in instruction-tuning datasets and rewriting underrepresented pre-training data into high-quality instruction-response pairs. This approach enriches dataset diversity while preserving task-specific objectives. Evaluations on three fully open LLMs across eight benchmarks demonstrate consistent performance improvements with AITP. Ablations highlight the benefits of adaptive data selection, controlled rewriting, and balanced integration, emphasizing the importance of aligning instruction tuning with pre-training distributions to unlock the full potential of LLMs.

Current alignment evaluation mostly measures whether models encode dangerous concepts and whether they refuse harmful requests. Both miss the layer where alignment often operates: routing from concept detection to behavioral policy. We study political censorship in Chinese-origin language models as a natural experiment, using probes, surgical ablations, and behavioral tests across nine open-weight models from five labs. Three findings follow. First, probe accuracy alone is non-diagnostic: political probes, null controls, and permutation baselines can all reach 100%, so held-out category generalization is the informative test. Second, surgical ablation reveals lab-specific routing. Removing the political-sensitivity direction eliminates censorship and restores accurate factual output in most models tested, while one model confabulates because its architecture entangles factual knowledge with the censorship mechanism. Cross-model transfer fails, indicating that routing geometry is model- and lab-specific. Third, refusal is no longer the dominant censorship mechanism. Within one model family, hard refusal falls to zero while narrative steering rises to the maximum, making censorship invisible to refusal-only benchmarks. These results support a three-stage descriptive framework: detect, route, generate. Models often retain the relevant knowledge; alignment changes how that knowledge is expressed. Evaluations that audit only detection or refusal therefore miss the routing mechanism that most directly determines behavior.

Currently, the neural network architecture design is mostly guided by the indirect metric of computation complexity, i.e., FLOPs. However, the direct metric, e.g., speed, also depends on the other factors such as memory access cost and platform characterics. Thus, this work proposes to evaluate the direct metric on the target platform, beyond only considering FLOPs. Based on a series of controlled experiments, this work derives several practical guidelines for efficient network design. Accordingly, a new architecture is presented, called ShuffleNet V2. Comprehensive ablation experiments verify that our model is the state-of-the-art in terms of speed and accuracy tradeoff.

Brazil's Unified Health System (SUS) relies on official clinical guidelines that define diagnostic criteria, treatments, dosages, and monitoring procedures for over 200 million citizens. Yet current LLMs perform poorly on this guideline-specific knowledge, and no benchmark evaluates clinical recall grounded in Brazilian Portuguese protocols. We address this gap by adapting Qwen2.5-14B-Instruct to the Brazilian clinical domain. From 178 official guidelines (~5.4M tokens), we generate ~70M tokens of synthetic data in three formats -- rephrases, wiki-style articles, and question-answer pairs -- using four generator LLMs. We then apply continual pre-training followed by Group Relative Policy Optimization (GRPO). We introduce HealthBench-BR, with 1,780 balanced true/false clinical assertions, and PCDT-QA, with 890 open-ended clinical questions scored by an LLM judge. Our best model achieves 83.9% on HealthBench-BR and 85.4% on PCDT-QA, outperforming GPT-5.2, Claude Sonnet 4.6, Gemini 3.1 Pro, and Google AI Overview's web-grounded RAG despite having only 14B parameters. Ablations show that generator diversity and reinforcement learning are critical to these gains. We release all datasets, benchmarks, and model weights to support reproducible clinical NLP research for Brazilian Portuguese. Code, data, and model weights are available at https://github.com/hugoabonizio/clinical-protocols-br

In long-horizon tasks, decision-relevant state is often scattered across an expanding trajectory, while the action agent must surface it and act. As trajectories grow, task requirements, environment facts, prior attempts, diagnoses, and open subgoals can be buried in the context window or pushed beyond it, failing to influence decisions when needed. We call this failure mode "behavioral state decay". We study memory as an active intervention mechanism rather than passive retrieval. A separate memory agent runs alongside an unmodified action agent, updating a structured memory bank from the recent trajectory and deciding whether to inject a memory-grounded reminder or remain silent. The module is plug-and-play with frontier action agents and existing agent harnesses. Across Terminal-Bench 2.0 and τ^2-Bench, it improves pass@1 for both weaker and stronger action agents, with gains of +8.3 pp on Terminal-Bench and +6.8 pp on τ^2-Bench. Ablations show that selective intervention outperforms passive bank exposure, always-on injection, advisor-only guidance, and general retrieval. As an early step toward open-weight memory policies, we train Qwen3.5-27B on SETA using SFT and GRPO, improving validation reward and achieving partial transfer to Terminal-Bench.

The prevalence of multi-modal content on social media complicates automated moderation strategies. This calls for an enhancement in multi-modal classification and a deeper understanding of understated meanings in images and memes. Although previous efforts have aimed at improving model performance through fine-tuning, few have explored an end-to-end optimization pipeline that accounts for modalities, prompting, labeling, and fine-tuning. In this study, we propose an end-to-end conceptual framework for model optimization in complex tasks. Experiments support the efficacy of this traditional yet novel framework, achieving the highest accuracy and AUROC. Ablation experiments demonstrate that isolated optimizations are not ineffective on their own.

Interpreting chest X-rays is inherently challenging due to the overlap between anatomical structures and the subtle presentation of many clinically significant pathologies, making accurate diagnosis time-consuming even for experienced radiologists. Recent radiology-focused foundation models, such as LLaVA-Rad and Maira-2, have positioned multi-modal large language models (MLLMs) at the forefront of automated radiology report generation (RRG). However, despite these advances, current foundation models generate reports in a single forward pass. This decoding strategy diminishes attention to visual tokens and increases reliance on language priors as generation proceeds, which in turn introduces spurious pathology co-occurrences in the generated reports. To mitigate these limitations, we propose Category-Wise Contrastive Decoding (CWCD), a novel and modular framework designed to enhance structured radiology report generation (SRRG). Our approach introduces category-specific parameterization and generates category-wise reports by contrasting normal X-rays with masked X-rays using category-specific visual prompts. Experimental results demonstrate that CWCD consistently outperforms baseline methods across both clinical efficacy and natural language generation metrics. An ablation study further elucidates the contribution of each architectural component to overall performance.

Adaptive moment methods such as Adam use a diagonal, coordinate-wise preconditioner based on exponential moving averages of squared gradients. This diagonal scaling is coordinate-system dependent and can struggle with dense or rotated parameter couplings, including those in matrix factorization, tensor decomposition, and graph neural networks, because it treats each parameter independently. We introduce FlowAdam, a hybrid optimizer that augments Adam with continuous gradient-flow integration via an ordinary differential equation (ODE). When EMA-based statistics detect landscape difficulty, FlowAdam switches to clipped ODE integration. Our central contribution is Soft Momentum Injection, which blends ODE velocity with Adam's momentum during mode transitions. This prevents the training collapse observed with naive hybrid approaches. Across coupled optimization benchmarks, the ODE integration provides implicit regularization, reducing held-out error by 10-22% on low-rank matrix/tensor recovery and 6% on Jester (real-world collaborative filtering), also surpassing tuned Lion and AdaBelief, while matching Adam on well-conditioned workloads (CIFAR-10). MovieLens-100K confirms benefits arise specifically from coupled parameter interactions rather than bias estimation. Ablation studies show that soft injection is essential, as hard replacement reduces accuracy from 100% to 82.5%.

Immunotherapy is an effective precision medicine treatment for several cancers. Imaging signatures of the underlying genome (radiogenomics) in glioblastoma patients may serve as preoperative biomarkers of the tumor-host immune apparatus. Validated biomarkers would have the potential to stratify patients during immunotherapy clinical trials, and if trials are beneficial, facilitate personalized neo-adjuvant treatment. The increased use of whole genome sequencing data, and the advances in bioinformatics and machine learning make such developments plausible. We performed a systematic review to determine the extent of development and validation of immune-related radiogenomic biomarkers for glioblastoma. A systematic review was performed following PRISMA guidelines using the PubMed, Medline, and Embase databases. Qualitative analysis was performed by incorporating the QUADAS 2 tool and CLAIM checklist. PROSPERO registered CRD42022340968. Extracted data were insufficiently homogenous to perform a meta-analysis. Results Nine studies, all retrospective, were included. Biomarkers extracted from magnetic resonance imaging volumes of interest included apparent diffusion coefficient values, relative cerebral blood volume values, and image-derived features. These biomarkers correlated with genomic markers from tumor cells or immune cells or with patient survival. The majority of studies had a high risk of bias and applicability concerns regarding the index test performed. Radiogenomic immune biomarkers have the potential to provide early treatment options to patients with glioblastoma. Targeted immunotherapy, stratified by these biomarkers, has the potential to allow individualized neo-adjuvant precision treatment options in clinical trials. However, there are no prospective studies validating these biomarkers, and interpretation is limited due to study bias with little evidence of generalizability.

Hyperparameter Optimization (HPO) is essential for building high-performing ML/DL models, yet conventional optimizers often struggle in high-dimensional spaces where evaluations are costly and progress is diluted across many low-impact variables. We propose Greedy Importance First (GIF), an importance-aware scheduling strategy that uses a small-sample warm start to estimate hyperparameter importance, forms importance-based groups, allocates trials proportionally, and retains a full-space fallback. We evaluate GIF under fixed evaluation budgets on five anisotropic analytic functions, Bayesmark, and NAS-Bench-301. On the higher-dimensional benchmarks, GIF reaches better incumbents with faster convergence than TPE, BOHB, Random Search, and Sequential Grouping. On Bayesmark, where the effective dimensionality is smaller, GIF remains competitive but the margins are smaller. Ablation studies show that importance estimation, proportional allocation, and the fallback step all contribute to the gains. We also verify that the HIA component recovers the intended anisotropy on the analytic benchmarks. These results suggest that GIF is a simple and plug-compatible way to improve sample efficiency in high-dimensional HPO.

Targeted data selection has emerged as a crucial paradigm for efficient instruction tuning, aiming to identify a small yet influential subset of training examples for a specific target task. In practice, influence is often measured through the effect of an example on parameter updates. To make selection scalable, many approaches leverage optimizer statistics (e.g., Adam states) as an axis-aligned surrogate for update geometry (i.e., diagonal precondition), implicitly treating parameters as coordinate-wise independent. We show that this assumption breaks down in parameter-efficient fine-tuning (PEFT) methods such as LoRA. In this setting, the induced optimization geometry exhibits strong cross-parameter coupling with non-trivial off-diagonal interactions, while the task-relevant update directions are confined to a low-dimensional subspace. Motivated by this mismatch, we propose GIST (Gradient Isometric Subspace Transformation), a simple yet principled alternative that replaces axis-aligned scaling with robust subspace alignment. GIST recovers a task-specific subspace from validation gradients via spectral filtering (SVD), projects training gradients into this coupled subspace, and scores examples by their alignment with target directions.Extensive experiments have demonstrated that GIST matches or outperforms the state-of-the-art baseline with only 0.29% of the storage and 25% of the computational time under the same selection budget.

In oncology, treating cancer with a beam of photons is a well established therapeutic technique, developed over 100 years, and today over 50% of cancer patients will undergo traditional X-ray radiotherapy. However, ionizing radiation therapy is not the only option, as the high-energy photons delivering their cell-killing radiation energy into cancerous tumor can lead to significant damage to healthy tissues surrounding the tumor, located throughout the beam's path. Therefore, in nowadays, advances in ionizing radiation therapy are competitive to non-ionizing ones, as for example the laser light based therapy, resulting in a synergism that has revolutionized medicine. The use of non-invasive or minimally invasive (e.g. through flexible endoscopes) therapeutic procedures in the management of patients represents a very interesting treatment option. Moreover, as the major breakthrough in cancer management is the individualized patient treatment, new biophotonic techniques, e.g. photo-activated drug carriers, help the improvement of treatment efficacy and/or normal tissue toxicity. Additionally, recent studies support that laser technology progresses could revolutionize cancer proton therapy, by reducing the cost of the needed installations. The aim of this review is to present some laser-based future objectives for cancer radiation therapy, aiming to address the relevant advances in the ionizing and non-ionizing radiation therapy, i.e. protons and heavy ions therapy, as well as photodynamic targeted and molecular therapies.

The common toxicity and societal bias in contents generated by large language models (LLMs) necessitate strategies to reduce harm. Present solutions often demand white-box access to the model or substantial training, which is impractical for cutting-edge commercial LLMs. Moreover, prevailing prompting methods depend on external tool feedback and fail to simultaneously lessen toxicity and bias. Motivated by social psychology principles, we propose a novel strategy named perspective-taking prompting (\textsc{PeT)} that inspires LLMs to integrate diverse human perspectives and self-regulate their responses. This self-correction mechanism can significantly diminish toxicity (up to 89%) and bias (up to 73%) in LLMs' responses. Rigorous evaluations and ablation studies are conducted on two commercial LLMs (ChatGPT and GLM) and three open-source LLMs, revealing PeT's superiority in producing less harmful responses, outperforming five strong baselines.

Diffusion large language models (dLLMs) generate text via iterative denoising but consistently underperform on multi-step reasoning. We hypothesize this gap stems from a coordination problem: AR models build coherence token-by-token, while diffusion models must coordinate all positions simultaneously. We propose plan conditioning, a training-free method that prepends a short (~100-token) natural-language plan from an AR model to the diffusion model's prompt. The plan serves as a frozen scaffold -- globally visible context that every token position can attend to from the first denoising step. On GSM8K, plan conditioning improves LLaDA-8B-Instruct from 75.6% to 87.2% (+11.6 percentage points), matching a same-size AR model (LLaMA 3.1 8B, 87.7%) despite a 6.4pp weaker baseline. On HumanEval, the gain is +12.8pp (37.2% to 50.0%), showing plans generalize to code. The same plans improve LLaMA by only +5.7pp on GSM8K and +1.3pp on HumanEval -- diffusion models benefit 2-10x more, supporting the coordination-problem hypothesis. Across 5 random seeds, plan-conditioned GSM8K accuracy has zero standard deviation, making diffusion inference highly stable. Ablations reveal the model follows plan strategy (wrong-strategy plans cause -16.3pp) but is robust to plan values (perturbed numbers: -1.1pp), and that planner quality has a sharp threshold: smaller Llama-class plans hurt (-1.6 to -6.8pp) while frontier plans provide the full lift. Attention analysis confirms the mechanism: plan tokens receive 1.8x excess attention during early denoising, declining to uniform as completion tokens solidify. Plan conditioning costs ~$0.002 per problem and adds ~2s of latency.

Histopathological cancer diagnostics has become more complex, and the increasing number of biopsies is a challenge for most pathology laboratories. Thus, development of automatic methods for evaluation of histopathological cancer sections would be of value. In this study, we used 624 whole slide images (WSIs) of breast cancer from a Norwegian cohort. We propose a cascaded convolutional neural network design, called H2G-Net, for semantic segmentation of gigapixel histopathological images. The design involves a detection stage using a patch-wise method, and a refinement stage using a convolutional autoencoder. To validate the design, we conducted an ablation study to assess the impact of selected components in the pipeline on tumour segmentation. Guiding segmentation, using hierarchical sampling and deep heatmap refinement, proved to be beneficial when segmenting the histopathological images. We found a significant improvement when using a refinement network for postprocessing the generated tumour segmentation heatmaps. The overall best design achieved a Dice score of 0.933 on an independent test set of 90 WSIs. The design outperformed single-resolution approaches, such as cluster-guided, patch-wise high-resolution classification using MobileNetV2 (0.872) and a low-resolution U-Net (0.874). In addition, segmentation on a representative x400 WSI took ~58 seconds, using only the CPU. The findings demonstrate the potential of utilizing a refinement network to improve patch-wise predictions. The solution is efficient and does not require overlapping patch inference or ensembling. Furthermore, we showed that deep neural networks can be trained using a random sampling scheme that balances on multiple different labels simultaneously, without the need of storing patches on disk. Future work should involve more efficient patch generation and sampling, as well as improved clustering.

Safety alignment mechanisms in large language models prevent responses to harmful queries through learned refusal behavior, yet these same mechanisms impede legitimate research applications including cognitive modeling, adversarial testing, and security analysis. While abliteration techniques enable surgical removal of refusal representations through directional orthogonalization, the relative effectiveness of available implementations remains uncharacterized. This study evaluates four abliteration tools (Heretic, DECCP, ErisForge, FailSpy) across sixteen instruction-tuned models (7B-14B parameters), reporting tool compatibility on all 16 models and quantitative metrics on subsets dictated by tool support. Single-pass methods demonstrated superior capability preservation on the benchmarked subset (avg GSM8K change across three models: ErisForge -0.28 pp; DECCP -0.13 pp), while Bayesian-optimized abliteration produced variable distribution shift (KL divergence: 0.043-1.646) with model-dependent capability impact. These findings provide researchers with evidence-based selection criteria for abliteration tool deployment across diverse model architectures. The principal finding indicates that mathematical reasoning capabilities exhibit the highest sensitivity to abliteration interventions, with GSM8K change ranging from +1.51 pp to -18.81 pp (-26.5% relative) depending on tool selection and model architecture.

Diffusion models have demonstrated impressive abilities in generating photo-realistic and creative images. To offer more controllability for the generation process, existing studies, termed as early-constraint methods in this paper, leverage extra conditions and incorporate them into pre-trained diffusion models. Particularly, some of them adopt condition-specific modules to handle conditions separately, where they struggle to generalize across other conditions. Although follow-up studies present unified solutions to solve the generalization problem, they also require extra resources to implement, e.g., additional inputs or parameter optimization, where more flexible and efficient solutions are expected to perform steerable guided image synthesis. In this paper, we present an alternative paradigm, namely Late-Constraint Diffusion (LaCon), to simultaneously integrate various conditions into pre-trained diffusion models. Specifically, LaCon establishes an alignment between the external condition and the internal features of diffusion models, and utilizes the alignment to incorporate the target condition, guiding the sampling process to produce tailored results. Experimental results on COCO dataset illustrate the effectiveness and superior generalization capability of LaCon under various conditions and settings. Ablation studies investigate the functionalities of different components in LaCon, and illustrate its great potential to serve as an efficient solution to offer flexible controllability for diffusion models.

Efficient, reliable and reproducible target volume delineation is a key step in the effective planning of breast radiotherapy. However, post-operative breast target delineation is challenging as the contrast between the tumor bed volume (TBV) and normal breast tissue is relatively low in CT images. In this study, we propose to mimic the marker-guidance procedure in manual target delineation. We developed a saliency-based deep learning segmentation (SDL-Seg) algorithm for accurate TBV segmentation in post-operative breast irradiation. The SDL-Seg algorithm incorporates saliency information in the form of markers' location cues into a U-Net model. The design forces the model to encode the location-related features, which underscores regions with high saliency levels and suppresses low saliency regions. The saliency maps were generated by identifying markers on CT images. Markers' locations were then converted to probability maps using a distance-transformation coupled with a Gaussian filter. Subsequently, the CT images and the corresponding saliency maps formed a multi-channel input for the SDL-Seg network. Our in-house dataset was comprised of 145 prone CT images from 29 post-operative breast cancer patients, who received 5-fraction partial breast irradiation (PBI) regimen on GammaPod. The performance of the proposed method was compared against basic U-Net. Our model achieved mean (standard deviation) of 76.4 %, 6.76 mm, and 1.9 mm for DSC, HD95, and ASD respectively on the test set with computation time of below 11 seconds per one CT volume. SDL-Seg showed superior performance relative to basic U-Net for all the evaluation metrics while preserving low computation cost. The findings demonstrate that SDL-Seg is a promising approach for improving the efficiency and accuracy of the on-line treatment planning procedure of PBI, such as GammaPod based PBI.

Prognostic Health Management (PHM) systems monitor and predict equipment health. A key task is Remaining Useful Life (RUL) estimation, which predicts how long a component, such as a rolling element bearing, will operate before failure. Many RUL methods exist but often lack generalizability and robustness under changing operating conditions. This paper introduces CARLE, a hybrid AI framework that combines deep and shallow learning to address these challenges. CARLE uses Res-CNN and Res-LSTM blocks with multi-head attention and residual connections to capture spatial and temporal degradation patterns, and a Random Forest Regressor (RFR) for stable, accurate RUL prediction. A compact preprocessing pipeline applies Gaussian filtering for noise reduction and Continuous Wavelet Transform (CWT) for time-frequency feature extraction. We evaluate CARLE on the XJTU-SY and PRONOSTIA bearing datasets. Ablation studies measure each component's contribution, while noise and cross-domain experiments test robustness and generalization. Comparative results show CARLE outperforms several state-of-the-art methods, especially under dynamic conditions. Finally, we analyze model interpretability with LIME and SHAP to assess transparency and trustworthiness.

Current tool-use large language models (LLMs) are trained on static datasets, enabling them to interact with external tools and perform multi-step, tool-integrated reasoning, which produces tool-call trajectories. However, these models imitate how a query is resolved in a generic tool-call routine, thereby failing to explore possible solutions and demonstrating limited performance in an evolved, dynamic tool-call environment. In this work, we propose PORTool, a reinforcement learning (RL) method that encourages a tool-use LLM to explore various trajectories yielding the correct answer. Specifically, this method starts with generating multiple rollouts for a given query, and some of them share the first few tool-call steps, thereby forming a tree-like structure. Next, we assign rewards to each step, based on its ability to produce a correct answer and make successful tool calls. A shared step across different trajectories receives the same reward, while different steps under the same fork receive different rewards. Finally, these step-wise rewards are used to calculate fork-relative advantages, blended with trajectory-relative advantages, to train the LLM for tool use. The experiments utilize 17 tools to address user queries, covering both time-sensitive and time-invariant topics. We conduct ablation studies to systematically justify the necessity and the design robustness of step-wise rewards. Furthermore, we compare the proposed PORTool with other training approaches and demonstrate significant improvements in final accuracy and the number of tool-call steps.

In an age characterized by the proliferation of mis- and disinformation online, it is critical to empower readers to understand the content they are reading. Important efforts in this direction rely on manual or automatic fact-checking, which can be challenging for emerging claims with limited information. Such scenarios can be handled by assessing the reliability and the political bias of the source of the claim, i.e., characterizing entire news outlets rather than individual claims or articles. This is an important but understudied research direction. While prior work has looked into linguistic and social contexts, we do not analyze individual articles or information in social media. Instead, we propose a novel methodology that emulates the criteria that professional fact-checkers use to assess the factuality and political bias of an entire outlet. Specifically, we design a variety of prompts based on these criteria and elicit responses from large language models (LLMs), which we aggregate to make predictions. In addition to demonstrating sizable improvements over strong baselines via extensive experiments with multiple LLMs, we provide an in-depth error analysis of the effect of media popularity and region on model performance. Further, we conduct an ablation study to highlight the key components of our dataset that contribute to these improvements. To facilitate future research, we released our dataset and code at https://github.com/mbzuai-nlp/llm-media-profiling.

Large Language Models (LLMs) have significantly advanced smart education in the Artificial General Intelligence (AGI) era. A promising application lies in the automatic generalization of instructional design for curriculum and learning activities, focusing on two key aspects: (1) Customized Generation: generating niche-targeted teaching content based on students' varying learning abilities and states, and (2) Intelligent Optimization: iteratively optimizing content based on feedback from learning effectiveness or test scores. Currently, a single large LLM cannot effectively manage the entire process, posing a challenge for designing intelligent teaching plans. To address these issues, we developed EduPlanner, an LLM-based multi-agent system comprising an evaluator agent, an optimizer agent, and a question analyst, working in adversarial collaboration to generate customized and intelligent instructional design for curriculum and learning activities. Taking mathematics lessons as our example, EduPlanner employs a novel Skill-Tree structure to accurately model the background mathematics knowledge of student groups, personalizing instructional design for curriculum and learning activities according to students' knowledge levels and learning abilities. Additionally, we introduce the CIDDP, an LLM-based five-dimensional evaluation module encompassing clarity, Integrity, Depth, Practicality, and Pertinence, to comprehensively assess mathematics lesson plan quality and bootstrap intelligent optimization. Experiments conducted on the GSM8K and Algebra datasets demonstrate that EduPlanner excels in evaluating and optimizing instructional design for curriculum and learning activities. Ablation studies further validate the significance and effectiveness of each component within the framework. Our code is publicly available at https://github.com/Zc0812/Edu_Planner

LLM agents often retry after external validation rejects a candidate, but the interface between validation and the next model call remains underspecified. We introduce VeriHarness, a code-controlled agent loop in which models generate candidates while external validators control acceptance, budgets, and traces. We use it to compare raw diagnostics with feedback that identifies the failure location, observed value, and admissible alternatives. Across 50 paired TextWorld games under a four-call cap, feedback containing all three fields raises terminal success from 14/50 to 36/50 for Qwen2.5-Coder-14B (+44 percentage points) and from 8/50 to 29/50 for Llama-3.1-8B (+42 points). Ablations locate most of the gain in the admissible alternatives: feedback containing only the location and observed value remains near the raw diagnostic baseline. Presenting the complete repair information in prose instead of a keyed JSON record yields nearly the same success, providing no evidence that JSON syntax itself improves repair. The ordering persists across the tested call budgets and one sampled-decoding setting.

We study short-horizon forecasting of weekly terrorism incident counts using the Global Terrorism Database (GTD, 1970--2016). We build a reproducible pipeline with fixed time-based splits and evaluate a Bidirectional LSTM (BiLSTM) against strong classical anchors (seasonal-naive, linear/ARIMA) and a deep LSTM-Attention baseline. On the held-out test set, the BiLSTM attains RMSE 6.38, outperforming LSTM-Attention (9.19; +30.6\%) and a linear lag-regression baseline (+35.4\% RMSE gain), with parallel improvements in MAE and MAPE. Ablations varying temporal memory, training-history length, spatial grain, lookback size, and feature groups show that models trained on long historical data generalize best; a moderate lookback (20--30 weeks) provides strong context; and bidirectional encoding is critical for capturing both build-up and aftermath patterns within the window. Feature-group analysis indicates that short-horizon structure (lagged counts and rolling statistics) contributes most, with geographic and casualty features adding incremental lift. We release code, configs, and compact result tables, and provide a data/ethics statement documenting GTD licensing and research-only use. Overall, the study offers a transparent, baseline-beating reference for GTD incident forecasting.

Advances in learning-based robotic manipulation, such as Vision-Language-Action (VLA) models and Video Action Models (VAMs), heavily rely on high-quality teleoperation data. Their capabilities are strictly upper-bounded by the quality of the underlying human demonstrations. Current gradient-based retargeting algorithms often converge to different local minima, resulting in jitter that affects data quality and teleoperation experience. To address this, we introduce the Sampling-Based Retargeter (SBR), a novel gradient-free retargeting method drawn from the rich literature of sampling-based control and explicitly designed for low-jitter, real-time kinematic retargeting. We evaluate SBR both in simulation and through a rigorous real-world user study involving 18 participants performing 3 complex manipulation tasks. Compared to gradient-based baselines, SBR achieved the highest overall task success rate (54.1%) while significantly reducing operator cognitive fatigue, recording the lowest NASA-TLX workload score (36.4 out of 100). Ultimately, we establish SBR as a highly effective, intuitive retargeter for dexterous manipulation, providing the community with a rigorous benchmarking methodology to guide future retargeting research.

Medical vision-language datasets are often limited in size and biased toward negative findings, as clinicians report abnormalities mostly but might omit some positive/neutral findings because they might be considered as irrelevant to the patient's condition. We propose a self-supervised data enrichment method that leverages semantic clustering of report sentences. Then we enrich the findings in the medical reports in the training set by adding positive/neutral observations from different clusters in a self-supervised manner. Our approach yields consistent gains in supervised fine-tuning (5.63%, 3.04%, 7.40%, 5.30%, 7.47% average gains on COMET score, Bert score, Sentence Bleu, CheXbert-F1 and RadGraph-F1 scores respectively). Ablation studies confirm that improvements stem from semantic clustering rather than random augmentation. Furthermore, we introduce a way to incorporate semantic cluster information into the reward design for GRPO training, which leads to further performance gains (2.78%, 3.14%, 12.80% average gains on COMET score, Bert score and Sentence Bleu scores respectively). We share our code at https://anonymous.4open.science/r/SemEnrich-75CF

Advances in voice conversion and text-to-speech synthesis have made automatic speaker verification (ASV) systems more susceptible to spoofing attacks. This work explores modest refinements to the AASIST anti-spoofing architecture. It incorporates a frozen Wav2Vec 2.0 encoder to retain self-supervised speech representations in limited-data settings, substitutes the original graph attention block with a standardized multi-head attention module using heterogeneous query projections, and replaces heuristic frame-segment fusion with a trainable, context-aware integration layer. When evaluated on the ASVspoof 5 corpus, the proposed system reaches a 7.6\% equal error rate (EER), improving on a re-implemented AASIST baseline under the same training conditions. Ablation experiments suggest that each architectural change contributes to the overall performance, indicating that targeted adjustments to established models may help strengthen speech deepfake detection in practical scenarios. The code is publicly available at https://github.com/KORALLLL/AASIST_SCALING.

Purpose: Magnetic resonance imaging (MRI) to visualize anatomical motion is becoming increasingly important when treating cancer patients with radiotherapy. Hybrid MRI-linear accelerator (MRI-linac) systems allow real-time motion management during irradiation. This paper presents a multi-institutional real-time MRI time series dataset from different MRI-linac vendors. The dataset is designed to support developing and evaluating real-time tumor localization (tracking) algorithms for MRI-guided radiotherapy within the TrackRAD2025 challenge (https://trackrad2025.grand-challenge.org/). Acquisition and validation methods: The dataset consists of sagittal 2D cine MRIs in 585 patients from six centers (3 Dutch, 1 German, 1 Australian, and 1 Chinese). Tumors in the thorax, abdomen, and pelvis acquired on two commercially available MRI-linacs (0.35 T and 1.5 T) were included. For 108 cases, irradiation targets or tracking surrogates were manually segmented on each temporal frame. The dataset was randomly split into a public training set of 527 cases (477 unlabeled and 50 labeled) and a private testing set of 58 cases (all labeled). Data Format and Usage Notes: The data is publicly available under the TrackRAD2025 collection: https://doi.org/10.57967/hf/4539. Both the images and segmentations for each patient are available in metadata format. Potential Applications: This novel clinical dataset will enable the development and evaluation of real-time tumor localization algorithms for MRI-guided radiotherapy. By enabling more accurate motion management and adaptive treatment strategies, this dataset has the potential to advance the field of radiotherapy significantly.

We develop an all-in-one computer vision toolbox named EasyCV to facilitate the use of various SOTA computer vision methods. Recently, we add YOLOX-PAI, an improved version of YOLOX, into EasyCV. We conduct ablation studies to investigate the influence of some detection methods on YOLOX. We also provide an easy use for PAI-Blade which is used to accelerate the inference process based on BladeDISC and TensorRT. Finally, we receive 42.8 mAP on COCO dateset within 1.0 ms on a single NVIDIA V100 GPU, which is a bit faster than YOLOv6. A simple but efficient predictor api is also designed in EasyCV to conduct end2end object detection. Codes and models are now available at: https://github.com/alibaba/EasyCV.

Dynamic MRI enables a range of clinical applications, including cardiac function assessment, organ motion tracking, and radiotherapy guidance. However, fully sampling the dynamic k-space data is often infeasible due to time constraints and physiological motion such as respiratory and cardiac motion. This necessitates undersampling, which degrades the quality of reconstructed images. Poor image quality not only hinders visualization but also impairs the estimation of deformation fields, crucial for registering dynamic (moving) images to a static reference image. This registration enables tasks such as motion correction, treatment planning, and quantitative analysis in applications like cardiac imaging and MR-guided radiotherapy. To overcome the challenges posed by undersampling and motion, we introduce an end-to-end deep learning (DL) framework that integrates adaptive dynamic k-space sampling, reconstruction, and registration. Our approach begins with a DL-based adaptive sampling strategy, optimizing dynamic k-space acquisition to capture the most relevant data for each specific case. This is followed by a DL-based reconstruction module that produces images optimized for accurate deformation field estimation from the undersampled moving data. Finally, a registration module estimates the deformation fields aligning the reconstructed dynamic images with a static reference. The proposed framework is independent of specific reconstruction and registration modules allowing for plug-and-play integration of these components. The entire framework is jointly trained using a combination of supervised and unsupervised loss functions, enabling end-to-end optimization for improved performance across all components. Through controlled experiments and ablation studies, we validate each component, demonstrating that each choice contributes to robust motion estimation from undersampled dynamic data.

The widespread use of chest X-rays (CXRs), coupled with a shortage of radiologists, has driven growing interest in automated CXR analysis and AI-assisted reporting. While existing vision-language models (VLMs) show promise in specific tasks such as report generation or abnormality detection, they often lack support for interactive diagnostic capabilities. In this work we present RadVLM, a compact, multitask conversational foundation model designed for CXR interpretation. To this end, we curate a large-scale instruction dataset comprising over 1 million image-instruction pairs containing both single-turn tasks -- such as report generation, abnormality classification, and visual grounding -- and multi-turn, multi-task conversational interactions. After fine-tuning RadVLM on this instruction dataset, we evaluate it across different tasks along with re-implemented baseline VLMs. Our results show that RadVLM achieves state-of-the-art performance in conversational capabilities and visual grounding while remaining competitive in other radiology tasks. Ablation studies further highlight the benefit of joint training across multiple tasks, particularly for scenarios with limited annotated data. Together, these findings highlight the potential of RadVLM as a clinically relevant AI assistant, providing structured CXR interpretation and conversational capabilities to support more effective and accessible diagnostic workflows.

This paper proposes a cold start recommendation model that integrates contrastive learning, aiming to solve the problem of performance degradation of recommendation systems in cold start scenarios due to the scarcity of user and item interaction data. The model dynamically adjusts the weights of key features through an adaptive feature selection module and effectively integrates user attributes, item meta-information, and contextual features by combining a multimodal feature fusion mechanism, thereby improving recommendation performance. In addition, the model introduces a contrastive learning mechanism to enhance the robustness and generalization ability of feature representation by constructing positive and negative sample pairs. Experiments are conducted on the MovieLens-1M dataset. The results show that the proposed model significantly outperforms mainstream recommendation methods such as Matrix Factorization, LightGBM, DeepFM, and AutoRec in terms of HR, NDCG, MRR, and Recall, especially in cold start scenarios. Ablation experiments further verify the key role of each module in improving model performance, and the learning rate sensitivity analysis shows that a moderate learning rate is crucial to the optimization effect of the model. This study not only provides a new solution to the cold start problem but also provides an important reference for the application of contrastive learning in recommendation systems. In the future, this model is expected to play a role in a wider range of scenarios, such as real-time recommendation and cross-domain recommendation.

Diffusion models have enabled remarkably high-quality medical image generation, yet it is challenging to enforce anatomical constraints in generated images. To this end, we propose a diffusion model-based method that supports anatomically-controllable medical image generation, by following a multi-class anatomical segmentation mask at each sampling step. We additionally introduce a random mask ablation training algorithm to enable conditioning on a selected combination of anatomical constraints while allowing flexibility in other anatomical areas. We compare our method ("SegGuidedDiff") to existing methods on breast MRI and abdominal/neck-to-pelvis CT datasets with a wide range of anatomical objects. Results show that our method reaches a new state-of-the-art in the faithfulness of generated images to input anatomical masks on both datasets, and is on par for general anatomical realism. Finally, our model also enjoys the extra benefit of being able to adjust the anatomical similarity of generated images to real images of choice through interpolation in its latent space. SegGuidedDiff has many applications, including cross-modality translation, and the generation of paired or counterfactual data. Our code is available at https://github.com/mazurowski-lab/segmentation-guided-diffusion.

We consider the problem of predicting how the likelihood of an outcome of interest for a patient changes over time as we observe more of the patient data. To solve this problem, we propose a supervised contrastive learning framework that learns an embedding representation for each time step of a patient time series. Our framework learns the embedding space to have the following properties: (1) nearby points in the embedding space have similar predicted class probabilities, (2) adjacent time steps of the same time series map to nearby points in the embedding space, and (3) time steps with very different raw feature vectors map to far apart regions of the embedding space. To achieve property (3), we employ a nearest neighbor pairing mechanism in the raw feature space. This mechanism also serves as an alternative to data augmentation, a key ingredient of contrastive learning, which lacks a standard procedure that is adequately realistic for clinical tabular data, to our knowledge. We demonstrate that our approach outperforms state-of-the-art baselines in predicting mortality of septic patients (MIMIC-III dataset) and tracking progression of cognitive impairment (ADNI dataset). Our method also consistently recovers the correct synthetic dataset embedding structure across experiments, a feat not achieved by baselines. Our ablation experiments show the pivotal role of our nearest neighbor pairing.

The U-Net architecture and its variants have remained state-of-the-art (SOTA) for retinal vessel segmentation over the past decade. In this study, we introduce a Full-Scale Guided Network (FSG-Net), where a novel feature representation module using modernized convolution blocks effectively captures full-scale structural information, while a guided convolution block subsequently refines this information. Specifically, we introduce an attention-guided filter within the guided convolution block, leveraging its similarity to unsharp masking to enhance fine vascular structures. Passing full-scale information to the attention block facilitates the generation of more contextually relevant attention maps, which are then passed to the attention-guided filter, providing further refinement to the segmentation performance. The structure preceding the guided convolution block can be replaced by any U-Net variant, ensuring flexibility and scalability across various segmentation tasks. For a fair comparison, we re-implemented recent studies available in public repositories to evaluate their scalability and reproducibility. Our experiments demonstrate that, despite its compact architecture, FSG-Net delivers performance competitive with SOTA methods across multiple public datasets. Ablation studies further demonstrate that each proposed component meaningfully contributes to this competitive performance. Our code is available on https://github.com/ZombaSY/FSG-Net-pytorch.

Recent scientific advances require complex experiment design, necessitating the meticulous tuning of many experiment parameters. Tree-structured Parzen estimator (TPE) is a widely used Bayesian optimization method in recent parameter tuning frameworks such as Hyperopt and Optuna. Despite its popularity, the roles of each control parameter in TPE and the algorithm intuition have not been discussed so far. The goal of this paper is to identify the roles of each control parameter and their impacts on parameter tuning based on the ablation studies using diverse benchmark datasets. The recommended setting concluded from the ablation studies is demonstrated to improve the performance of TPE. Our TPE implementation used in this paper is available at https://github.com/nabenabe0928/tpe/tree/single-opt. OptunaHub now provides our standalone TPE implementation at https://hub.optuna.org/samplers/tpe_tutorial/.

We present our winning system for Task~B (generation with reference passages) in SemEval-2026 Task~8: MTRAGEval. Our method is a heterogeneous ensemble of seven LLMs with two prompting variants, where a GPT-4o-mini judge selects the best candidate per instance. We ranked 1st out of 26 teams, achieving a conditioned harmonic mean of 0.7827 and outperforming the strongest baseline (gpt-oss-120b, 0.6390). Ablations show that diversity in model families, scales, and prompting strategies is essential, with the ensemble consistently beating any single model. We also introduce Meno-Lite-0.1, a 7B domain-adapted model with a strong cost--performance trade-off, and analyse MTRAGEval, highlighting annotation limitations and directions for improvement. Our code is publicly available: https://github.com/RaguTeam/ragu_mtrag_semeval

Neural Architecture Search (NAS) is an exciting new field which promises to be as much as a game-changer as Convolutional Neural Networks were in 2012. Despite many great works leading to substantial improvements on a variety of tasks, comparison between different methods is still very much an open issue. While most algorithms are tested on the same datasets, there is no shared experimental protocol followed by all. As such, and due to the under-use of ablation studies, there is a lack of clarity regarding why certain methods are more effective than others. Our first contribution is a benchmark of 8 NAS methods on 5 datasets. To overcome the hurdle of comparing methods with different search spaces, we propose using a method's relative improvement over the randomly sampled average architecture, which effectively removes advantages arising from expertly engineered search spaces or training protocols. Surprisingly, we find that many NAS techniques struggle to significantly beat the average architecture baseline. We perform further experiments with the commonly used DARTS search space in order to understand the contribution of each component in the NAS pipeline. These experiments highlight that: (i) the use of tricks in the evaluation protocol has a predominant impact on the reported performance of architectures; (ii) the cell-based search space has a very narrow accuracy range, such that the seed has a considerable impact on architecture rankings; (iii) the hand-designed macro-structure (cells) is more important than the searched micro-structure (operations); and (iv) the depth-gap is a real phenomenon, evidenced by the change in rankings between 8 and 20 cell architectures. To conclude, we suggest best practices, that we hope will prove useful for the community and help mitigate current NAS pitfalls. The code used is available at https://github.com/antoyang/NAS-Benchmark.

Respiratory diseases remain major global health challenges, and traditional auscultation is often limited by subjectivity, environmental noise, and inter-clinician variability. This study presents an explainable multimodal deep learning framework for automatic lung-disease detection using respiratory audio signals. The proposed system integrates two complementary representations: a spectral-temporal encoder based on a CNN-BiLSTM Attention architecture, and a handcrafted acoustic-feature encoder capturing physiologically meaningful descriptors such as MFCCs, spectral centroid, spectral bandwidth, and zero-crossing rate. These branches are combined through late-stage fusion to leverage both data-driven learning and domain-informed acoustic cues. The model is trained and evaluated on the Asthma Detection Dataset Version 2 using rigorous preprocessing, including resampling, normalization, noise filtering, data augmentation, and patient-level stratified partitioning. The study achieved strong generalization with 91.21% accuracy, 0.899 macro F1-score, and 0.9866 macro ROC-AUC, outperforming all ablated variants. An ablation study confirms the importance of temporal modeling, attention mechanisms, and multimodal fusion. The framework incorporates Grad-CAM, Integrated Gradients, and SHAP, generating interpretable spectral, temporal, and feature-level explanations aligned with known acoustic biomarkers to build clinical transparency. The findings demonstrate the framework's potential for telemedicine, point-of-care diagnostics, and real-world respiratory screening.

Dense per-step supervision is an appealing remedy for sparse-reward, long-horizon LLM agents: reward the agent for predicting its next observation, and memory should follow. We show that under group-normalized RL (GRPO), this recipe does not merely fail -- it destroys the policy. Across Qwen3-1.7B/4B/8B on ALFWorld, a potential-based prediction reward drives every run into a degenerate absorbing state (prediction accuracy -> 1.0, task success -> 0,episode length pinned at the horizon): the "dark room" pathology, built automatically by the optimizer. A single-factor ablation localizes the cause -- removing only GRPO's std normalization turns the same reward from catastrophic (0%) into baseline parity -- and a two-line proposition explains why: in all-fail groups the z-scored advantage is invariant to the shaping coefficient, so bounded rewards become unbounded pressure and annealing cannot help. Our central insight generalizes this: what z-scoring amplifies is a dense signal's within-group variance while all-fail groups dominate, so signals whose variance decays by mastery are structurally amplifier-safe.This variance-profile criterion retrodicts our collapses, carries preregistered predictions for arms that had not yet run, and is consistent with published reward-channel successes (a compatibility check, not an independent test). Finally, a controlled signal-delivery matrix (identical signal, varying only the consumption mechanism) shows the reward channel is at best neutral while the auxiliary-loss channel gains ~20 points -- and a shuffled-gold placebo matches the true-gold arm, so the gap survives without correct labels. Endpoints are single-seed; seed replication and group-size controls are preregistered and in progress.

Heart failure is a leading cause of global mortality, necessitating improved diagnostic strategies. Classical machine learning models struggle with challenges such as high-dimensional data, class imbalances, poor feature representations, and a lack of interpretability. While quantum machine learning holds promise, current hybrid models have not fully exploited quantum advantages. In this paper, we propose the Kolmogorov-Arnold Classical-Quantum Dual-Channel Neural Network (KACQ-DCNN), a novel hybrid architecture that replaces traditional multilayer perceptrons with Kolmogorov-Arnold Networks (KANs), enabling learnable univariate activation functions. Our KACQ-DCNN 4-qubit, 1-layer model outperforms 37 benchmark models, including 16 classical and 12 quantum neural networks, achieving an accuracy of 92.03%, with macro-average precision, recall, and F1 scores of 92.00%. It also achieved a ROC-AUC of 94.77%, surpassing other models by significant margins, as validated by paired t-tests with a significance threshold of 0.0056 (after Bonferroni correction). Ablation studies highlight the synergistic effect of classical-quantum integration, improving performance by about 2% over MLP variants. Additionally, LIME and SHAP explainability techniques enhance feature interpretability, while conformal prediction provides robust uncertainty quantification. Our results demonstrate that KACQ-DCNN improves cardiovascular diagnostics by combining high accuracy with interpretability and uncertainty quantification.

Alarm fatigue in intensive care units (ICUs) is a well documented patient safety crisis. Clinical monitors generate 350 or more alarms per patient per day, out of which 72-99% are clinically irrelevant. Staff desensitization to non-actionable alarms increases the risk of missed true emergencies. This paper presents SigmaMedStat, a machine learning system that evaluates the trustworthiness of physiological alarm signals before clinical action is taken. Four approaches were evaluated on the PhysioNet/Computing in Cardiology Challenge 2015 dataset of 498 four-channel ICU alarm recordings. Primary contribution is a temporal modeling framework that splits each 60 second recording into six consecutive 10-second chunks, and this in turn generates Continuous Wavelet Transform (CWT) scalograms per chunk, encodes each chunk with a shared EfficientNet-B0 encoder, and passes the resulting feature sequence to a two-layer Long Short-Term Memory (LSTM) network. Five-fold stratified cross-validation yields a mean AUC of 0.822 +/- 0.016 (95% CI: [0.790,0.853]), compared to 0.641 for a static EfficientNet baseline trained on the full 60-second window. Ablation studies confirm that temporal chunking and multi-channel signal fusion both contribute independently to classification performance. Per-alarm type analysis reveals that Ventricular Flutter is the most accurately classified alarm type (AUC 0.820) while Asystole remains the hardest (AUC 0.722). Error analysis identifies 65 false negatives and 85 high-confidence misclassifications as the primary failure modes. All code and results are publicly available at https://github.com/Arun-K-Ram/sigmamedstat.

Multi-site neuroimaging analysis is fundamentally confounded by scanner-induced covariate shifts, where the marginal distribution of voxel intensities P(x) varies non-linearly across acquisition protocols while the conditional anatomy P(y|x) remains constant. This is particularly detrimental to radiomic reproducibility, where acquisition variance often exceeds biological pathology variance. Existing statistical harmonization methods (e.g., ComBat) operate in feature space, precluding spatial downstream tasks, while standard deep learning approaches are theoretically bounded by local effective receptive fields (ERF), failing to model the global intensity correlations characteristic of field-strength bias. We propose SA-CycleGAN-2.5D, a domain adaptation framework motivated by the HΔH-divergence bound of Ben-David et al., integrating three architectural innovations: (1) A 2.5D tri-planar manifold injection preserving through-plane gradients nabla_z at O(HW) complexity; (2) A U-ResNet generator with dense voxel-to-voxel self-attention, surpassing the O(L) receptive field limit of CNNs to model global scanner field biases; and (3) A spectrally-normalized discriminator constraining the Lipschitz constant (K_D le 1) for stable adversarial optimization. Evaluated on 654 glioma patients across two institutional domains (BraTS and UPenn-GBM), our method reduces Maximum Mean Discrepancy (MMD) by 99.1% (1.729 to 0.015) and degrades domain classifier accuracy to near-chance (59.7%). Ablation confirms that global attention is statistically essential (Cohen's d = 1.32, p < 0.001) for the harder heterogeneous-to-homogeneous translation direction. By bridging 2D efficiency and 3D consistency, our framework yields voxel-level harmonized images that preserve tumor pathophysiology, enabling reproducible multi-center radiomic analysis.

Medical coding is essential for standardizing clinical data and communication but is often time-consuming and prone to errors. Traditional Natural Language Processing (NLP) methods struggle with automating coding due to the large label space, lengthy text inputs, and the absence of supporting evidence annotations that justify code selection. Recent advancements in Generative Artificial Intelligence (AI) offer promising solutions to these challenges. In this work, we introduce MedCodER, a Generative AI framework for automatic medical coding that leverages extraction, retrieval, and re-ranking techniques as core components. MedCodER achieves a micro-F1 score of 0.60 on International Classification of Diseases (ICD) code prediction, significantly outperforming state-of-the-art methods. Additionally, we present a new dataset containing medical records annotated with disease diagnoses, ICD codes, and supporting evidence texts (https://doi.org/10.5281/zenodo.13308316). Ablation tests confirm that MedCodER's performance depends on the integration of each of its aforementioned components, as performance declines when these components are evaluated in isolation.