LiteFold/InterPro · Datasets at Hugging Face

IPR061455

61,455

Mercury methylation corrinoid protein HgcA-like

HgcA-like

Family

725

false

This entry represents the mercury methylation corrinoid protein HgcA from Pseudodesulfovibrio mercurii ( ) and similar prokaryotic proteins. HgcA and HgcB occur in a number of anaerobic bacteria and archaea, and are responsible for conversion of inorganic mercury to methylmercury, a highly toxic organomercurial compoun...

[]

0

[ "NCBIFAM" ]

[ "NF040863" ]

[ "HgcA_corrinoid" ]

[ 725 ]

1

[]

0

[]

0

[ "PUB00105933", "PUB00106029" ]

[ "36598231", "23393089" ]

[ "Eight Unexpected Selenoprotein Families in Organometallic Biochemistry in Clostridium difficile, in ABC Transport, and in Methylmercury Biosynthesis.", "The genetic basis for bacterial mercury methylation." ]

[ 2023, 2013 ]

2

[]

0

null

[ "Bacteria", "Methanomicrobia", "Paratrimastix pyriformis", "unclassified sequences" ]

[ 185, 37, 1, 502 ]

4

[]

0

true

Family

Mercury methylation corrinoid protein HgcA-like

HgcA-like

4

IPR061456

61,456

Serine/threonine-protein kinase B/F, N-terminal domain

SPKB/F_N

Domain

2,533

false

This entry represents the N-terminal short domain of Serine/threonine-protein kinase B/F from Synechocystis sp. (SKPB/F) and similar proteins from cyanobacteria. SKPB is thought to be required for cell motility, but not for phototaxis. Most proteins with this N-terminal domain are protein serine/threonine protein kinas...

[]

0

[ "NCBIFAM" ]

[ "NF045510" ]

[ "4Cys_prefix_kin" ]

[ 2533 ]

1

[]

0

[]

0

[ "PUB00154656" ]

[ "22530622" ]

[ "Thiol-based redox modulation of a cyanobacterial eukaryotic-type serine/threonine kinase required for oxidative stress tolerance." ]

[ 2012 ]

1

[]

0

null

[ "Archaea", "Bacteria", "Eukaryota" ]

[ 3, 2528, 2 ]

3

[]

0

true

Domain

Serine/threonine-protein kinase B/F, N-terminal domain

SPKB/F_N

5

IPR061457

61,457

FxsB-like, C-terminal domain

FxsB-like_C

Domain

188

false

This entry represents the C-terminal extension domain with inactivated beta-hydroxylase, in which the HEXXH motif usually seen is missing. While that motif is well known to occur widely in different families of zinc-dependent metalloproteases, the HEXXH motif in was shown instead to bind a non-heme iron in a peptide-mo...

[]

0

[ "NCBIFAM" ]

[ "NF040587" ]

[ "rSAM_lost_HExxH" ]

[ 188 ]

1

[]

0

[]

0

[ "PUB00105843", "PUB00159285" ]

[ "34164914", "39294420" ]

[ "Post-Translational Formation of Aminomalonate by a Promiscuous Peptide-Modifying Radical SAM Enzyme.", "Fused radical SAM and αKG-HExxH domain proteins contain a distinct structural fold and catalyse cyclophane formation and β-hydroxylation." ]

[ 2021, 2024 ]

2

[]

0

null

[ "Streptomycetaceae" ]

[ 188 ]

1

[]

0

true

Domain

FxsB-like, C-terminal domain

FxsB-like_C

5

IPR061461

61,461

PxKF C-terminal domain

PxKF_C

Domain

505

false

This entry represents the PxKF domain at the C-terminal of uncharacterised extracellular proteins. These proteins are usually largely surface-associated proteins, processed and anchored by the type IX secretion system, exosortases, rhombosortases, etc. These proteins are mostly found in Actinobacteria, but also some Fi...

[]

0

[ "NCBIFAM" ]

[ "NF038114" ]

[ "rightmost" ]

[ 505 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Archaea", "Bacteria", "CS clade", "metagenomes" ]

[ 5, 478, 18, 4 ]

4

[]

0

true

Domain

PxKF C-terminal domain

PxKF_C

1

IPR061462

61,462

UU173/MG366

Family

162

false

This entry represents Uncharacterized protein UU173, MG366 and MG366 homologue found in Mycoplasmatota. UU173 is encoded next to an element that encodes UU172 , a phase-variable surface membrane protein paralogous to multiple-banded antigen (MBA) [ ]. This protein contains an uncharacterised domain represented by .

[]

0

[ "NCBIFAM" ]

[ "NF045869" ]

[ "UU173_fam" ]

[ 162 ]

1

[]

0

[]

0

[ "PUB00159629" ]

[ "21255110" ]

[ "Ureaplasma antigenic variation beyond MBA phase variation: DNA inversions generating chimeric structures and switching in expression of the MBA N-terminal paralogue UU172." ]

[ 2011 ]

1

[]

0

null

[ "Mycoplasmatota" ]

[ 162 ]

1

[]

0

true

Family

UU173/MG366

7

IPR061463

61,463

PG0327-like

Family

474

false

Members of this family of apparent multi-membrane-spanning proteins include CD0519 and CD1768 from Clostridium difficile, PG0327 from Porphyromonas gingivalis, and TDE2325 from Treponema denticola. Some members contain the Gate domain represented by .

[]

0

[ "NCBIFAM" ]

[ "NF049989" ]

[ "CD0519_CD1768" ]

[ 474 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 469, 5 ]

2

[]

0

true

Family

PG0327-like

2

IPR061465

61,465

LppU/SCO3897 domain

SCO3897

Domain

3,522

false

This domain, with four near-invariant Cys residues, occurs in a single copy at the C-terminal region of SCO3897 from Streptomyces coelicolor, a protein reported to be involved in species differentiation. The N-terminal region of that protein is rich in Gly, Pro, and Gln. This domain also occurs in the putative lipoprot...

[]

0

[ "NCBIFAM" ]

[ "NF049863" ]

[ "differ_SCO3897" ]

[ 3522 ]

1

[]

0

[]

0

[ "PUB00162903" ]

[ "20012957" ]

[ "SCO3900, co-transcripted with three downstream genes, is involved in the differentiation of Streptomyces coelicolor." ]

[ 2010 ]

1

[]

0

null

[ "Bacteria", "Didymella rabiei", "freshwater metagenome" ]

[ 3520, 1, 1 ]

3

[]

0

true

Domain

LppU/SCO3897 domain

SCO3897

2

IPR061466

61,466

LipL31

Family

123

false

Members of this family are lipoprotein LipL31 , as described in Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 but found broadly in the genus Leptospira. Close homologues lacking a lipoprotein signal sequence likely reflect errors in their annotated coding regions.

[]

0

[ "NCBIFAM" ]

[ "NF033166" ]

[ "lipo_LipL31" ]

[ 123 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Leptospira" ]

[ 123 ]

1

[]

0

true

Family

LipL31

1

IPR061470

61,470

SseB

Family

1,376

false

SseB appears to be found exclusively in Enterobacteria. SseB enhances serine-sensitivity in Escherichia coli [ ] and is part of the Salmonella pathogenicity island 2 (SPI-2) translocon [ ].

[]

0

[ "NCBIFAM" ]

[ "NF008624" ]

[ "PRK11611.1" ]

[ 1376 ]

1

[]

0

[]

0

[ "PUB00013031", "PUB00013032", "PUB00159854" ]

[ "7982894", "12724372", "8722098" ]

[ "Enhancement of serine-sensitivity by a gene encoding rhodanese-like protein in Escherichia coli.", "SseA is a chaperone for the SseB and SseD translocon components of the Salmonella pathogenicity-island-2-encoded type III secretion system.", "Isolation and characterization of chromosomal mTn 10 insertion mutat...

[ 1994, 2003, 1996 ]

3

[]

0

null

[ "Bacteria", "Opisthokonta" ]

[ 1374, 2 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

SseB

6

IPR061472

61,472

Elastin-binding protein EbpS

EbpS

Family

104

false

This entry represents the elastin-binding protein EbpS. EbpS is an adhesin described in S.aureus, with orthologues found in many additional staphylococcal species. It promotes binding of soluble elastin peptides and tropoelastin to S.aureus cells although it is not able to promote bacterial adherence to immobilised ela...

[]

0

[ "NCBIFAM" ]

[ "NF033598" ]

[ "elast_bind_EbpS" ]

[ 104 ]

1

[]

0

[]

0

[ "PUB00105189", "PUB00105190", "PUB00105191" ]

[ "11684686", "24787448", "8663124" ]

[ "The elastin-binding protein of Staphylococcus aureus (EbpS) is expressed at the cell surface as an integral membrane protein and not as a cell wall-associated protein.", "The staphylococcal elastin-binding protein regulates zinc-dependent growth/biofilm formation.", "Molecular cloning and expression of the gen...

[ 2002, 2014, 1996 ]

3

[]

0

null

[ "Staphylococcus", "human gut metagenome" ]

[ 103, 1 ]

2

[]

0

true

Family

Elastin-binding protein EbpS

EbpS

4

IPR061473

61,473

AuxA

Family

187

false

AuxA is an apparent membrane protein and probable transporter found in methicillin-resistant Staphylococcus aureus (MRSA). It contributes to lipoteichoic acid (LTA) stability and therefore to beta-lactam resistance phenotype that depends primarily on the cell wall biosynthesis enzyme PBP2a encoded by mecA [ ].

[]

0

[ "NCBIFAM" ]

[ "NF047417" ]

[ "teichoic_AuxA" ]

[ 187 ]

1

[]

0

[]

0

[ "PUB00159163" ]

[ "33503451" ]

[ "The Novel Membrane-Associated Auxiliary Factors AuxA and AuxB Modulate β-lactam Resistance in MRSA by stabilizing Lipoteichoic Acids." ]

[ 2021 ]

1

[]

0

null

[ "Bacillales", "human gut metagenome" ]

[ 186, 1 ]

2

[]

0

true

Family

AuxA

2

IPR061474

61,474

Cell envelope integrity protein Cei

Cei

Family

947

false

This entry represents Cell envelope integrity protein Cei. Cei is a transmembrane protein with an extracellular LytR_C domain . It lacks any DNA-binding domain and is not a transcriptional regulator. It shares homology to C-terminal regions present in some members of the LytR-CpsA-Psr family, a family in which some cha...

[]

0

[ "NCBIFAM" ]

[ "NF035953" ]

[ "integrity_Cei" ]

[ 947 ]

1

[]

0

[ "6q10" ]

1

[ "PUB00105468" ]

[ "31285241" ]

[ "Mycobacterium tuberculosis Rv2700 Contributes to Cell Envelope Integrity and Virulence." ]

[ 2019 ]

1

[]

0

null

[ "Actinomycetes" ]

[ 947 ]

1

[]

0

true

Family

Cell envelope integrity protein Cei

Cei

7

IPR061475

61,475

AraC family transcriptional regulator Rsp

Rsp

Family

91

false

Rsp (repressor of surface proteins), as described in Staphylococcus aureus, is a large protein with an AraC-like helix-turn-helix DNA-binding domain. Regulatory targets include the accessory gene regulator (agr) operon, which in turn regulates a large number of virulence factors [ , ]. Rsp contains a helix-turn-helix d...

[]

0

[ "NCBIFAM" ]

[ "NF033869" ]

[ "viru_reg_Rsp" ]

[ 91 ]

1

[]

0

[]

0

[ "PUB00105386", "PUB00105387" ]

[ "26712209", "30028663" ]

[ "AraC-Type Regulator Rsp Adapts Staphylococcus aureus Gene Expression to Acute Infection.", "Naturally occurring polymorphisms in the virulence regulator Rsp modulate Staphylococcus aureus survival in blood and antibiotic susceptibility." ]

[ 2015, 2018 ]

2

[]

0

null

[ "Bacillales" ]

[ 91 ]

1

[]

0

true

Family

AraC family transcriptional regulator Rsp

Rsp

8

IPR061476

61,476

Uncharacterized HTH-type transcriptional regulator SACOL0084

SACOL0084

Family

84

false

SACOL0084 (also known as AryK) is a AraC/XylS family transcriptional regulator in the genus Streptococcus. In S. aureus, AryK affects virulence factor gene expression and toxin production. Orthologues in other staphylococcal species may be quite difference in sequence, and their role is not well characterised [ ]. This...

[]

0

[ "NCBIFAM" ]

[ "NF047455" ]

[ "TF_Staph_AryK" ]

[ 84 ]

1

[]

0

[]

0

[ "PUB00159164" ]

[ "24512075" ]

[ "Hyperexpression of α-hemolysin explains enhanced virulence of sequence type 93 community-associated methicillin-resistant Staphylococcus aureus." ]

[ 2014 ]

1

[]

0

null

[ "Staphylococcaceae" ]

[ 84 ]

1

[]

0

true

Family

Uncharacterized HTH-type transcriptional regulator SACOL0084

SACOL0084

2

IPR061477

61,477

Acidic double-disulfide repeat

Acid_disulf_rpt

Repeat

87

false

The acidic double-disulphide repeat is an Asp-rich repeat with four nearly invariant Cys residues in a repeat length of about 35 amino acids. This repeat can be found in a variety of uncharacterised proteins from bacteria and eukaryotes. It can be found also repeated once or multiple times.

[]

0

[ "NCBIFAM" ]

[ "NF033662" ]

[ "acid_disulf_rpt" ]

[ 87 ]

1

[]

0

[ "7plp" ]

1

[]

0

[]

0

null

[ "Bacteria", "Candidatus Iainarchaeum sp.", "Eukaryota" ]

[ 62, 2, 23 ]

3

[]

0

true

Repeat

Acidic double-disulfide repeat

Acid_disulf_rpt

4

IPR061478

61,478

Type VI secretion system-associated protein TagK

T6SS_TagK

Family

513

false

This entry represents Type VI secretion system-associated protein TagK found in bacteria. Members of this family have full-length homology to SciF , a type VI secretion system (T6SS) protein from Salmonella typhimurium island SPI-6. Members contain an unstructured C-terminal domain and an N-terminal domain with a β-she...

[]

0

[ "NCBIFAM" ]

[ "NF033418" ]

[ "T6SS_TagK" ]

[ 513 ]

1

[]

0

[]

0

[ "PUB00105085", "PUB00105086" ]

[ "17660433", "22961625" ]

[ "In vivo expression technology identifies a type VI secretion system locus in Burkholderia pseudomallei that is induced upon invasion of macrophages.", "The type VI secretion system gene cluster of Salmonella typhimurium: required for full virulence in mice." ]

[ 2007, 2013 ]

2

[]

0

null

[ "Pseudomonadota", "Strongyloides venezuelensis" ]

[ 512, 1 ]

2

[]

0

true

Family

Type VI secretion system-associated protein TagK

T6SS_TagK

2

IPR061479

61,479

MAG4270 putative restriction endonuclease

MAG4270

Family

71

false

Members of this family are largely restricted to the Mycoplasmatota, including members of the genera Mycoplasma, Mycoplasmopsis, and Spiroplasma. The C-terminal region is distantly related to the type II restriction enzyme HphI and to HNH family endonucleases . Members are regularly found encoded next to a MAG4250 fami...

[]

0

[ "NCBIFAM" ]

[ "NF045952" ]

[ "MAG4270_fam" ]

[ 71 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria" ]

[ 71 ]

1

[]

0

true

Family

MAG4270 putative restriction endonuclease

MAG4270

3

IPR061480

61,480

MAG1360

Family

63

false

Members of this family, found in the Mycoplasmatota, resemble the ATP-binding protein OppF of oligopeptide transporters, but lack the P-loop motif (GxxGxGKT) that signifies ATP-binding.

[]

0

[ "NCBIFAM" ]

[ "NF045976" ]

[ "MAG1360_fam" ]

[ 63 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Mycoplasmatota" ]

[ 63 ]

1

[]

0

true

Family

MAG1360

5

IPR061481

61,481

Lonely Cys repeat

Lonely_Cys

Repeat

152

false

This entry represents a repeat found in Streptomyces. This repeat contains an extremely low cysteine composition, one residue per domain with an essentially invariant position.

[]

0

[ "NCBIFAM" ]

[ "NF012197" ]

[ "lonely_Cys" ]

[ 152 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Actinomycetes" ]

[ 152 ]

1

[]

0

true

Repeat

Lonely Cys repeat

Lonely_Cys

3

IPR061483

61,483

NlpE

Family

1,294

false

Lipoprotein NlpE is a multifunctional outer membrane lipoprotein implicated in copper homeostasis, potentially contributing to both copper efflux and the delivery of copper to copper-dependent enzymes [ ]. It is required for efficient adhesion of stationary-phase cells to hydrophobic surfaces, a key step in biofilm for...

[]

0

[ "NCBIFAM" ]

[ "NF007814" ]

[ "PRK10523.1" ]

[ 1294 ]

1

[]

0

[ "2z4h", "2z4i" ]

2

[ "PUB00009886", "PUB00010108", "PUB00050195", "PUB00159866", "PUB00163368" ]

[ "7635807", "11830644", "17698001", "15252048", "7635808" ]

[ "Identification of cutC and cutF (nlpE) genes involved in copper tolerance in Escherichia coli.", "Surface sensing and adhesion of Escherichia coli controlled by the Cpx-signaling pathway.", "Structural studies of the Cpx pathway activator NlpE on the outer membrane of Escherichia coli.", "Effects of lipoprot...

[ 1995, 2002, 2007, 2004, 1995 ]

5

[]

0

null

[ "Bacteria", "Trichuris trichiura" ]

[ 1293, 1 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

NlpE

2

IPR061484

61,484

Megatron

GTA_megatron

Family

1,669

false

Members of this family are multidomain proteins with full-length sequence homology to a gene transfer agent (GTA) baseplate multidomain protein called Megatron. GTA is related to HK97 and SPP1 phage. Megatron includes a central TIM barrel domain .

[]

0

[ "NCBIFAM" ]

[ "NF048004" ]

[ "GTA_megatron" ]

[ 1669 ]

1

[]

0

[ "6tba", "6teh" ]

2

[ "PUB00153971" ]

[ "32541663" ]

[ "Structure and mechanism of DNA delivery of a gene transfer agent." ]

[ 2020 ]

1

[]

0

null

[ "Pseudomonadota", "Viruses", "metagenomes" ]

[ 1648, 11, 10 ]

3

[]

0

true

Family

Megatron

GTA_megatron

8

IPR061485

61,485

CadC

Family

1,122

false

CadC is an integral membrane protein of 512 amino acids comprising an N-terminal cytoplasmic DNA-binding domain , a transmembrane helix, and a C-terminal periplasmic domain. It belongs to the ToxR-like regulators, a family of biochemically unmodified one-component systems with similar topology that includes several low...

[]

0

[ "NCBIFAM" ]

[ "NF007540" ]

[ "PRK10153.1" ]

[ 1122 ]

1

[]

0

[ "3ly7", "3ly8", "3ly9", "3lya" ]

4

[ "PUB00055284", "PUB00104567", "PUB00104568", "PUB00163369", "PUB00163370", "PUB00163371", "PUB00163372" ]

[ "21308846", "16491024", "24946151", "1370290", "18086202", "21216950", "28432336" ]

[ "Crystal structure of the sensory domain of Escherichia coli CadC, a member of the ToxR-like protein family.", "CadC-mediated activation of the cadBA promoter in Escherichia coli.", "Topology, dimerization, and stability of the single-span membrane protein CadC.", "Identification of elements involved in trans...

[ 2011, 2005, 2014, 1992, 2008, 2011, 2017 ]

7

[]

0

null

[ "Bacteria", "Trichuris trichiura" ]

[ 1121, 1 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

CadC

9

IPR061486

61,486

Major outer sheath protein

MOSP

Family

676

false

Major outer sheath proteins are present on the bacterial cell surface. In Treponema denticola the major outer sheath protein (Msp) binds immobilized laminin and fibronectin, supporting the hypothesis that Msp mediates the extracellular matrix binding activity of T. denticola [ ].

[]

0

[ "NCBIFAM" ]

[ "NF033926" ]

[ "msp_porin" ]

[ 676 ]

1

[]

0

[]

0

[ "PUB00007575", "PUB00105429", "PUB00105430", "PUB00105431", "PUB00109193", "PUB00162776" ]

[ "9023187", "22661689", "25225245", "8626313", "23457251", "29038532" ]

[ "Conservation of msp, the gene encoding the major outer membrane protein of oral Treponema spp.", "Comparative investigation of the genomic regions involved in antigenic variation of the TprK antigen among treponemal species, subspecies, and strains.", "Antigenic variation of TprK facilitates development of sec...

[ 1997, 2012, 2014, 1996, 2013, 2017 ]

6

[]

0

null

[ "Treponema" ]

[ 676 ]

1

[]

0

true

Family

Major outer sheath protein

MOSP

8

IPR061487

61,487

Internalin H

InlH

Family

66

false

This entry represents Internalin H which contributes to systemic listeriosis in mice by decreasing host IL-6 cytokine production and thus evasion of the host immune response. It does not contribute to invasion of the host intestinal tissue [ ].

[]

0

[ "NCBIFAM" ]

[ "NF033188" ]

[ "internalin_H" ]

[ 66 ]

1

[]

0

[]

0

[ "PUB00105019", "PUB00163373" ]

[ "17764999", "20176794" ]

[ "Internalins: a complex family of leucine-rich repeat-containing proteins in Listeria monocytogenes.", "The stress-induced virulence protein InlH controls interleukin-6 production during murine listeriosis." ]

[ 2007, 2010 ]

2

[]

0

null

[ "Listeria monocytogenes" ]

[ 66 ]

1

[]

0

true

Family

Internalin H

InlH

7

IPR061488

61,488

RQC-related

Family

76

false

This entry represents RQC-related proteins that usually contain the RQC domain .

[]

0

[ "NCBIFAM" ]

[ "NF041108" ]

[ "RQC_minor_2" ]

[ 76 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacillales" ]

[ 76 ]

1

[]

0

true

Family

RQC-related

2

IPR061490

61,490

Immunomodulating metalloprotease

ImpA

Family

324

false

ImpA degrades several host immune system proteins, thereby subverting leukocyte-mediated defense mechanisms. It cleaves P-selectin glycoprotein ligand-1 (PSGL-1), a leukocyte cell-surface receptor essential for recruitment to sites of infection, leading to its functional inhibition. The protease also targets CD43 and C...

[]

0

[ "NCBIFAM" ]

[ "NF038322" ]

[ "ImpA_fam_HExGH" ]

[ 324 ]

1

[]

0

[ "5kdv", "5kdw", "5kdx", "7jtv" ]

4

[ "PUB00091230", "PUB00105720" ]

[ "22309196", "31527124" ]

[ "Identification of an immunomodulating metalloprotease of Pseudomonas aeruginosa (IMPa).", "Pseudomonas aeruginosa ExsA Regulates a Metalloprotease, ImpA, That Inhibits Phagocytosis of Macrophages." ]

[ 2012, 2019 ]

2

[]

0

null

[ "Bacteria", "Opisthokonta", "hydrothermal vent metagenome" ]

[ 315, 8, 1 ]

3

[]

0

true

Family

Immunomodulating metalloprotease

ImpA

5

IPR061491

61,491

Conjugal transfer protein TraO

TraO

Family

659

false

TraO , involved in the conjugal transfer of plasmids such as IncI1 plasmids, shares homology with IcmE of type IVB secretion systems.

[]

0

[ "NCBIFAM" ]

[ "NF033884" ]

[ "conj_TraO_IncI1" ]

[ 659 ]

1

[]

0

[]

0

[ "PUB00105401" ]

[ "25477379" ]

[ "High-resolution genetic analysis of the requirements for horizontal transmission of the ESBL plasmid from Escherichia coli O104:H4." ]

[ 2015 ]

1

[]

0

null

[ "Plasmid R64", "Pseudomonadota", "Trichuris trichiura", "bioreactor metagenome" ]

[ 1, 656, 1, 1 ]

4

[]

0

true

Family

Conjugal transfer protein TraO

TraO

7

IPR061493

61,493

LEA family epithelial adhesin, N-terminal domain

LEA_N

Domain

44

false

LEA (Lactobacillus epithelium adhesin) is a large, repetitive protein with an N-terminal YSIRK-type signal peptide and a C-terminal LPXTG site for processing by sortase and attachment to the cell surface. Family members contain variable numbers of repeats similar to Lactobacillus Rib/alpha-like repeats. This entry desc...

[]

0

[ "NCBIFAM" ]

[ "NF033647" ]

[ "adhesin_LEA" ]

[ 44 ]

1

[]

0

[]

0

[ "PUB00105218" ]

[ "22516222" ]

[ "Identification of a high-molecular-mass Lactobacillus epithelium adhesin (LEA) of Lactobacillus crispatus ST1 that binds to stratified squamous epithelium." ]

[ 2012 ]

1

[]

0

null

[ "Lactobacillaceae" ]

[ 44 ]

1

[]

0

true

Domain

LEA family epithelial adhesin, N-terminal domain

LEA_N

3

IPR061494

61,494

Choice-of-anchor O protein

Choice_anch_O

Family

56

false

Members of this entry display variable C-terminal regions: some possess a JDVT-CTERM sorting signal, others carry a divergent GlyGly-CTERM domain, and the remainder have C-terminal sequences not currently recognised as sorting signals or known homology domains. The function of this family remains unknown. These protein...

[]

0

[ "NCBIFAM" ]

[ "NF040591" ]

[ "choice_anch_O" ]

[ 56 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "Eukaryota" ]

[ 53, 3 ]

2

[]

0

true

Family

Choice-of-anchor O protein

Choice_anch_O

4

IPR061495

61,495

Albusnodin lasso peptide

Lasso_albusnod

Family

74

false

Members of this family are lasso peptides in the family of albusnodin , and appear limited so far to the Actinobacteria. Members are more strongly conserved in the core peptide region than in the leader peptide region, which is unusual for ribosomally produced, post-translationally modified natural products. The foundi...

[]

0

[ "NCBIFAM" ]

[ "NF033525" ]

[ "lasso_albusnod" ]

[ 74 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Actinomycetes" ]

[ 74 ]

1

[]

0

true

Family

Albusnodin lasso peptide

Lasso_albusnod

2

IPR061497

61,497

Antigenic heat-stable 120 kDa protein

Sca4

Family

273

false

Sca4 (surface cell antigen 4 or Antigenic heat-stable 120 kDa protein) is a surface protein of Rickettsia (intracellular pathogens) that mediates protrusion from an infected cell and engulfment by the adjacent cell in order to mediate spreading [ , ].

[]

0

[ "NCBIFAM" ]

[ "NF038365" ]

[ "Sca4_fam" ]

[ 273 ]

1

[]

0

[ "4lq8" ]

1

[ "PUB00105746", "PUB00105747" ]

[ "21841197", "27768890" ]

[ "The rickettsia surface cell antigen 4 applies mimicry to bind to and activate vinculin.", "Rickettsia Sca4 Reduces Vinculin-Mediated Intercellular Tension to Promote Spread." ]

[ 2011, 2016 ]

2

[]

0

null

[ "Rickettsia" ]

[ 273 ]

1

[]

0

true

Family

Antigenic heat-stable 120 kDa protein

Sca4

5

IPR061499

61,499

MXAN_6640 putative metalloprotease domain

MXAN_6640_HExxH

Domain

337

false

Members of this entry are probably metalloproteases with an invariant HExxH motif. The domain may be found as a surface-anchored protein, as various members have the MYXO_CTERM sorting domain, the CFI-box-CTERM domain (NF041770), or the T9SS type A sorting domain. Some proteins are associated with .

[]

0

[ "NCBIFAM" ]

[ "NF045524" ]

[ "MXAN_6640_HExxH" ]

[ 337 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteria", "metagenomes" ]

[ 310, 27 ]

2

[]

0

true

Domain

MXAN_6640 putative metalloprotease domain

MXAN_6640_HExxH

5

IPR061500

61,500

Invasion protein InvF

IvnF

Family

443

false

This entry represents Invasion protein InvF. IvnF is a transcriptional regulator required for the expression of several genes encoding type III secretion system SPI1 effector proteins. The interaction with SicA is necessary for the activation of sigDE (sopB pipC), sicAsipBCDA, and sopE [ , , , ]. This protein contains ...

[]

0

[ "NCBIFAM" ]

[ "NF011868" ]

[ "PRK15340.1" ]

[ 443 ]

1

[]

0

[]

0

[ "PUB00163374", "PUB00163375", "PUB00163376", "PUB00163377" ]

[ "10417179", "10438766", "10692170", "11296219" ]

[ "Differential regulation of Salmonella typhimurium type III secreted proteins by pathogenicity island 1 (SPI-1)-encoded transcriptional activators InvF and hilA.", "InvF is required for expression of genes encoding proteins secreted by the SPI1 type III secretion apparatus in Salmonella typhimurium.", "The puta...

[ 1999, 1999, 2000, 2001 ]

4

[]

0

null

[ "Pseudomonadota" ]

[ 443 ]

1

[]

0

true

Family

Invasion protein InvF

IvnF

6

IPR061502

61,502

Copia/RE1/RE2-like, N-terminal domain

Copia/RE1/RE2-like_N

Domain

83,496

false

This entry includes LTR-polyproteins, or retrotransposons of the copia-type. It can be found at the N-terminal of Copia from Drosophila melanogaster, RE1 and RE2 from Arabidopsis and related sequences from plants, fungi and arthropods. These are LTR-polyproteins, or retrotransposons of the copia-type. The function of t...

[]

0

[ "PFAM" ]

[ "PF14223" ]

[ "Retrotran_gag_2" ]

[ 83496 ]

1

[ "EC", "EC" ]

[ "2.7.7.49", "3.4.23.-" ]

[ "EC:2.7.7.49", "EC:3.4.23.-" ]

2

[ "8s41", "8vvw", "8vvz", "8vw3", "8vwg" ]

5

[ "PUB00089767" ]

[ "2538806" ]

[ "The nucleotide sequence of Drosophila melanogaster copia-specific 2.1-kb mRNA." ]

[ 1989 ]

1

[]

0

null

[ "Atrato Retro-like virus", "Bacteria", "Eukaryota" ]

[ 2, 17, 83477 ]

3

[ "Arabidopsis thaliana", "Danio rerio", "Drosophila melanogaster", "Oryza sativa subsp. japonica", "Zea mays" ]

[ 169, 1, 3, 713, 48 ]

5

true

Domain

Copia/RE1/RE2-like, N-terminal domain

Copia/RE1/RE2-like_N

5

IPR061503

61,503

HTH-type transcriptional regulator AcrR

AcrR

Family

1,229

false

This protein family includes HTH-type transcriptional regulator AcrR from Escherichia coli and similar sequences from enterobacterales. AcrR represses the expression of target genes, including the efflux pump subunits AcrA and AcrB. It may play a role in detoxification or efflux of putrescine independently from the Acr...

[ "GO:0003700", "GO:0006355" ]

[ "DNA-binding transcription factor activity", "regulation of DNA-templated transcription" ]

[ "molecular_function", "biological_process" ]

2

[ "NCBIFAM" ]

[ "NF007949" ]

[ "PRK10668.1" ]

[ 1229 ]

1

[]

0

[ "2qop", "3bcg", "3lhq" ]

3

[ "PUB00163395", "PUB00163396", "PUB00163397" ]

[ "17644067", "36416552", "37787551" ]

[ "Characterization of the multidrug efflux regulator AcrR from Escherichia coli.", "The Multidrug Efflux Regulator AcrR of Escherichia coli Responds to Exogenous and Endogenous Ligands To Regulate Efflux and Detoxification.", "The multidrug efflux pump regulator AcrR directly represses motility in <i>Escherichia...

[ 2007, 2022, 2023 ]

3

[ "IPR050624" ]

[]

1

0

1

[ "Bacteria", "Opisthokonta" ]

[ 1227, 2 ]

2

[ "Escherichia coli (strain K12)" ]

[ 1 ]

1

true

Family

HTH-type transcriptional regulator AcrR

AcrR

9

IPR061504

61,504

Efflux pump membrane transporter MexY-like

MexY-like

Family

201

false

This protein family includes Efflux pump membrane transporter MexY from Pseudomonas aeruginosa ( ) and similar sequences from beta and gammaproteobacteria. MexY is an inner membrane transporter component of the MexXY-OprM efflux system that confers multidrug resistance [ , , ], which shows activity against quinolones, ...

[]

0

[ "NCBIFAM" ]

[ "NF007131" ]

[ "PRK09577.1" ]

[ 201 ]

1

[]

0

[ "8z1u", "9e9f" ]

2

[ "PUB00163399", "PUB00163400", "PUB00163401", "PUB00163402", "PUB00163403" ]

[ "10543738", "11083635", "12654672", "15325256", "40042268" ]

[ "Involvement of an active efflux system in the natural resistance of Pseudomonas aeruginosa to aminoglycosides.", "Substrate specificities of MexAB-OprM, MexCD-OprJ, and MexXY-oprM efflux pumps in Pseudomonas aeruginosa.", "MexXY-OprM efflux pump is necessary for a adaptive resistance of Pseudomonas aeruginosa ...

[ 1999, 2000, 2003, 2004, 2025 ]

5

[ "IPR004764" ]

[]

1

0

1

[ "Pseudomonadota" ]

[ 201 ]

1

[]

0

true

Family

Efflux pump membrane transporter MexY-like

MexY-like

4

IPR061505

61,505

Multidrug resistance protein MexX

MexX

Family

180

false

This protein family includes Multidrug resistance protein MexX from Pseudomonas aeruginosa ( ) and similar sequences from beta and gammaproteobacteria. MexX is a periplasmic adapter component of the MexXY-OprM efflux system that confers multidrug resistance [ , , ], which shows activity against quinolones, macrolides, ...

[ "GO:0046677" ]

[ "response to antibiotic" ]

[ "biological_process" ]

1

[ "NCBIFAM" ]

[ "NF007132" ]

[ "PRK09578.1" ]

[ 180 ]

1

[]

0

[]

0

[ "PUB00163399", "PUB00163400", "PUB00163402" ]

[ "10543738", "11083635", "15325256" ]

[ "Involvement of an active efflux system in the natural resistance of Pseudomonas aeruginosa to aminoglycosides.", "Substrate specificities of MexAB-OprM, MexCD-OprJ, and MexXY-oprM efflux pumps in Pseudomonas aeruginosa.", "Role of the membrane fusion protein in the assembly of resistance-nodulation-cell divisi...

[ 1999, 2000, 2004 ]

3

[ "IPR006143" ]

[]

1

0

1

[ "Pseudomonadota" ]

[ 180 ]

1

[]

0

true

Family

Multidrug resistance protein MexX

MexX

6

IPR061506

61,506

MCM2, N-terminal

MCM2_N

Domain

4,356

false

This entry represents the N-terminal region of MCM2 which acts a component of the MCM2-7 complex (MCM complex), the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. It is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that ...

[]

0

[ "PFAM" ]

[ "PF12619" ]

[ "MCM2_N" ]

[ 4356 ]

1

[ "EC", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", ...

[ "3.6.4.12", "R-DME-176187", "R-DME-68867", "R-DME-68949", "R-DME-68962", "R-DME-69052", "R-HSA-176187", "R-HSA-176974", "R-HSA-68867", "R-HSA-68949", "R-HSA-68962", "R-HSA-69052", "R-HSA-9825895", "R-MMU-176187", "R-MMU-68867", "R-MMU-68949", "R-MMU-68962", "R-MMU-69052", "R-SCE-...

[ "EC:3.6.4.12", "REACTOME:R-DME-176187", "REACTOME:R-DME-68867", "REACTOME:R-DME-68949", "REACTOME:R-DME-68962", "REACTOME:R-DME-69052", "REACTOME:R-HSA-176187", "REACTOME:R-HSA-176974", "REACTOME:R-HSA-68867", "REACTOME:R-HSA-68949", "REACTOME:R-HSA-68962", "REACTOME:R-HSA-69052", "REACTOME:...

31

[ "3ja8", "3jc5", "3jc6", "3jc7", "4uuz", "5bk4", "5bnv", "5bnx", "5bo0", "5c3i", "5ja4", "5u8s", "5u8t", "5v8f", "5xf8", "6eyc", "6f0l", "6hv9", "6ptj", "6ptn", "6pto", "6raw", "6rax", "6ray", "6raz", "6rqc", "6skl", "6sko", "6wgf", "6wgg", "6wgi", "6xtx"...

92

[ "PUB00053343", "PUB00078068", "PUB00151996", "PUB00154055", "PUB00154917", "PUB00154918" ]

[ "16369567", "25618846", "35585232", "32453425", "34694004", "34700328" ]

[ "The ATPase activity of MCM2-7 is dispensable for pre-RC assembly but is required for DNA unwinding.", "Structural insight into how the human helicase subunit MCM2 may act as a histone chaperone together with ASF1 at the replication fork.", "Fast and efficient DNA replication with purified human proteins.", "...

[ 2005, 2015, 2022, 2020, 2021, 2021 ]

6

[]

0

null

[ "Eukaryota" ]

[ 4356 ]

1

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 10, 2, 1, 1, 6, 3, 1, 1, 2, 1, 1, 9 ]

12

true

Domain

MCM2, N-terminal

MCM2_N

5

IPR061507

61,507

Protein of unknown function DUF3316

DUF3316

Family

489

false

This entry represents a family of uncharacterised proteins mainly found in bacteroidales. Some members are annotated as outer membrane proteins. Its specific function is unknown.

[]

0

[ "PFAM" ]

[ "PF11777" ]

[ "DUF3316" ]

[ 489 ]

1

[]

0

[]

0

[]

0

[]

0

null

[ "Bacteroidota", "metagenomes" ]

[ 479, 10 ]

2

[]

0

true

Family

Protein of unknown function DUF3316

DUF3316

6

IPR061508

61,508

Histone H2A, histone fold

HFD_H2A

Domain

31,324

false

This entry represents the histone fold. Histone H2A is a small, highly conserved nuclear protein that, together with two molecules each of histones H2B, H3 and H4, forms the eukaryotic nucleosome core [ ]; the nucleosome octamer winds ~146 DNA base-pairs. In the mouse, histone H2A can be replaced by histone H2A-like 1 ...

[]

0

[ "CDD" ]

[ "cd00074" ]

[ "HFD_H2A" ]

[ 31324 ]

1

[ "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOME", "REACTOM...

[ "R-BTA-110330", "R-BTA-110331", "R-BTA-171306", "R-BTA-201722", "R-BTA-212300", "R-BTA-2299718", "R-BTA-2559580", "R-BTA-2559582", "R-BTA-2559586", "R-BTA-3214815", "R-BTA-3214847", "R-BTA-3214858", "R-BTA-427359", "R-BTA-427413", "R-BTA-5250924", "R-BTA-5578749", "R-BTA-5625886", ...

[ "REACTOME:R-BTA-110330", "REACTOME:R-BTA-110331", "REACTOME:R-BTA-171306", "REACTOME:R-BTA-201722", "REACTOME:R-BTA-212300", "REACTOME:R-BTA-2299718", "REACTOME:R-BTA-2559580", "REACTOME:R-BTA-2559582", "REACTOME:R-BTA-2559586", "REACTOME:R-BTA-3214815", "REACTOME:R-BTA-3214847", "REACTOME:R-B...

254

[ "1aoi", "1eqz", "1f66", "1hio", "1hq3", "1id3", "1kx3", "1kx4", "1kx5", "1m18", "1m19", "1m1a", "1p34", "1p3a", "1p3b", "1p3f", "1p3g", "1p3i", "1p3k", "1p3l", "1p3m", "1p3o", "1p3p", "1s32", "1tzy", "1u35", "1zbb", "1zla", "2aro", "2cv5", "2f8n", "2fj7"...

965

[ "PUB00004260", "PUB00004448", "PUB00037830", "PUB00040100", "PUB00061022", "PUB00078304", "PUB00085658", "PUB00088027", "PUB00088115", "PUB00100521", "PUB00101224", "PUB00101225", "PUB00112321", "PUB00135287", "PUB00137713", "PUB00147445", "PUB00150375", "PUB00156073", "PUB001560...

[ "9305837", "8121801", "16107708", "15951514", "20498094", "24140421", "17261847", "24463511", "16359901", "24352239", "26974126", "26974124", "9519294", "25470042", "22713238", "28506460", "29280735", "30718488", "30053102", "29643509", "27992841", "27462807", "2587222", ...

[ "Crystal structure of the nucleosome core particle at 2.8 A resolution.", "Phylogenetic analysis of the core histones H2A, H2B, H3, and H4.", "Structural characterization of the histone variant macroH2A.", "Alteration of the nucleosomal DNA path in the crystal structure of a human nucleosome core particle.", ...

[ 1997, 1994, 2005, 2005, 2010, 2013, 2007, 2014, 2005, 2014, 2016, 2016, 1998, 2014, 2012, 2017, 2017, 2019, 2018, 2018, 2017, 2016, 1989, 2004, 2004, 2005, 2006, 2006, 2018, 2013, 2013, 2014, 2015, 2016 ]

34

[ "IPR007125" ]

[]

1

0

1

[ "Eukaryota", "Pseudomonadota", "Viruses", "metagenomes" ]

[ 31302, 2, 12, 8 ]

4

[ "Arabidopsis thaliana", "Caenorhabditis elegans", "Danio rerio", "Drosophila melanogaster", "Homo sapiens", "Mus musculus", "Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)", "Oryza sativa subsp. japonica", "Rattus norvegicus", "Saccharomyces cerevisiae (strai...

[ 43, 6, 31, 3, 49, 43, 2, 20, 56, 3, 3, 113 ]

12

true

Domain

Histone H2A, histone fold

HFD_H2A

4